Molecular structure of AG 556, CAS Number: 133550-41-1
AG 556 (CAS 133550-41-1)
Application:
AG 556 is inhibitor of EGFR kinase autophosphorylation over HER1/2 autophosphorylation
CAS Number:
133550-41-1
Purity:
≥98%
Molecular Weight:
336.4
Molecular Formula:
C20H20N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG 556 selectively inhibits epidermal growth factor receptor kinase autophosphorylation (IC50 = 5μM) over HER1/2 autophosphorylation. Also blocks LPS-induced TNF-α production. AG 556 is an inhibitor of EGFR.
AG 556 (CAS 133550-41-1) References
- Effect of tyrosine kinase inhibition on sepsis-induced vascular hyporesponsiveness, inos mrna expression and NF-kappaB nuclear translocation in rats. | Klein, SM., et al. 2000. Shock. 14: 544-9. PMID: 11092687
- Genistein and tyrphostin AG 556 block the action potential shortening in septic shock. | Chiang, CE., et al. 2002. Zhonghua Yi Xue Za Zhi (Taipei). 65: 570-9. PMID: 12636202
- Effects of the tyrosine kinase inhibitor tyrphostin AG 556 on acute necrotising pancreatitis in rats. | Alhan, E., et al. 2002. Eur J Surg. 168: 557-62. PMID: 12666696
- Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. | George, J., et al. 2003. Exp Mol Pathol. 74: 314-8. PMID: 12782020
- The effects of tyrphostine Ag 556 on experimental spinal cord ischemia reperfusion injury. | Usul, H., et al. 2004. Surg Neurol. 61: 45-54; discussion 54. PMID: 14706378
- Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. | Jaleel, M., et al. 2004. Biochemistry. 43: 8247-55. PMID: 15209521
- The effect of tyrphostin AG-556 on intimal thickening in a mouse model of arterial injury. | George, J., et al. 2005. Exp Mol Pathol. 78: 233-8. PMID: 15924877
- Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. | Gazit, A., et al. 1991. J Med Chem. 34: 1896-907. PMID: 1676428
- Investigation of tyrphostin AG 556 for testicular torsion-induced ischemia reperfusion injury in rat. | Karaguzel, E., et al. 2014. J Pediatr Urol. 10: 223-9. PMID: 24070787
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. | Osherov, N., et al. 1993. J Biol Chem. 268: 11134-42. PMID: 8098709
- Tyrphostin AG 556 improves survival and reduces multiorgan failure in canine Escherichia coli peritonitis. | Sevransky, JE., et al. 1997. J Clin Invest. 99: 1966-73. PMID: 9109441
- Suppression of experimental autoimmune encephalomyelitis by tyrphostin AG-556. | Brenner, T., et al. 1998. Exp Neurol. 154: 489-98. PMID: 9878184
Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 556, 5 mg | sc-202044 | 5 mg | $32.00 | |||
AG 556, 25 mg | sc-202044A | 25 mg | $64.00 |