Molecular structure of AG 555, CAS Number: 133550-34-2
AG 555 (CAS 133550-34-2)
See product citations (3)
Alternate Names:
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide; Tyrphostin AG 555
Application:
AG 555 is a potent epidermal growth factor receptor kinase inhibitor
CAS Number:
133550-34-2
Molecular Weight:
322.36
Molecular Formula:
C19H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG 555 is a potent EGFR (epidermal growth factor receptor) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. AG 555 induces G1 growth arrest selectively in transformed cells (IC50 values are 6.4 and 9.4 μM in HPV16-immortalized and normal keratinocytes respectively).
AG 555 (CAS 133550-34-2) References
- Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. | Ben-Bassat, H., et al. 1999. J Pharmacol Exp Ther. 290: 1442-57. PMID: 10454524
- Tyrphostin AG 555 inhibits bovine papillomavirus transcription by changing the ratio between E2 transactivator/repressor function. | Baars, S., et al. 2003. J Biol Chem. 278: 37306-13. PMID: 12867421
- Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. | Gazit, A., et al. 1991. J Med Chem. 34: 1896-907. PMID: 1676428
- Tyrphostin AG-555 inhibits early and late stages of Moloney murine leukemia virus replication cycle. | Seri, I., et al. 1997. Int J Oncol. 10: 1185-9. PMID: 21533502
- Tyrosine kinase inhibition: an approach to drug development. | Levitzki, A. and Gazit, A. 1995. Science. 267: 1782-8. PMID: 7892601
- Inhibition of topoisomerase I activity by tyrphostin derivatives, protein tyrosine kinase blockers: mechanism of action. | Aflalo, E., et al. 1994. Cancer Res. 54: 5138-42. PMID: 7923131
- The p15 matrix protein of moloney murine leukemia virus is a phosphotyrosine protein. | Seri, I. and Priel, E. 1996. FEBS Lett. 392: 229-32. PMID: 8774850
- Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells. | Klein, BY., et al. 1997. J Cell Biochem. 65: 420-9. PMID: 9138097
- Tyrphostin AG 494 blocks Cdk2 activation. | Osherov, N. and Levitzki, A. 1997. FEBS Lett. 410: 187-90. PMID: 9237626
- Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. | Ben-Bassat, H., et al. 1997. Cancer Res. 57: 3741-50. PMID: 9288782
Inhibitor of:
EGFR, and GRK 3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 555, 10 mg | sc-203500 | 10 mg | $71.00 | |||
| US: Only available in the US | ||||||
AG 555, 50 mg | sc-203500A | 50 mg | $344.00 | |||
| US: Only available in the US | ||||||