Molecular structure of AG 494, CAS Number: 133550-35-3
AG 494 (CAS 133550-35-3)
Alternate Names:
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
Application:
AG 494 is a potent and selective inhibitor of EGFR tyrosine kinase
CAS Number:
133550-35-3
Purity:
>98%
Molecular Weight:
280.28
Molecular Formula:
C16H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).
AG 494 (CAS 133550-35-3) References
- Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. | Ben-Bassat, H., et al. 1999. J Pharmacol Exp Ther. 290: 1442-57. PMID: 10454524
- Silica-induced nuclear factor-kappaB activation: involvement of reactive oxygen species and protein tyrosine kinase activation. | Kang, JL., et al. 2000. J Toxicol Environ Health A. 60: 27-46. PMID: 10832616
- Nitric oxide up-regulates DNA-binding activity of nuclear factor-kappaB in macrophages stimulated with silica and inflammatory stimulants. | Kang, JL., et al. 2000. Mol Cell Biochem. 215: 1-9. PMID: 11204443
- Tyrphostins protect neuronal cells from oxidative stress. | Sagara, Y., et al. 2002. J Biol Chem. 277: 36204-15. PMID: 12121989
- Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. | Tomlins, SA., et al. 2005. Exp Cell Res. 308: 439-45. PMID: 15950968
- Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. | Gazit, A., et al. 1991. J Med Chem. 34: 1896-907. PMID: 1676428
- The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. | Bojko, A., et al. 2012. Folia Histochem Cytobiol. 50: 186-95. PMID: 22763976
- Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. | Liu, X., et al. 2013. J Cell Mol Med. 17: 1160-72. PMID: 23844832
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells. | Bojko, A., et al. 2015. Nutr Cancer. 67: 1170-82. PMID: 26364505
- Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins. | Osherov, N., et al. 1993. J Biol Chem. 268: 11134-42. PMID: 8098709
- Tyrphostin AG 494 blocks Cdk2 activation. | Osherov, N. and Levitzki, A. 1997. FEBS Lett. 410: 187-90. PMID: 9237626
- Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase. | Kleinberger-Doron, N., et al. 1998. Exp Cell Res. 241: 340-51. PMID: 9637776
Inhibitor of:
EGFR, and PDGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 494, 10 mg | sc-202043 | 10 mg | $69.00 | |||
AG 494, 50 mg | sc-202043A | 50 mg | $255.00 |