Molecular structure of AG-1296, CAS Number: 146535-11-7
AG-1296 (CAS 146535-11-7)
See product citations (6)
Alternate Names:
6,7-Dimethoxy-3-phenylquinoxaline;Tyrphostin AG 1296
Application:
AG-1296 is a potent inhibitor of PDGFR kinase and c-Kit
CAS Number:
146535-11-7
Purity:
>98%
Molecular Weight:
266.29
Molecular Formula:
C16H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG-1296 is a potent and selective inhibitor of PDGFR kinase (IC50= 0.4 muM) both in vitro and in cells (Swiss 3T3 cells). This compound also inhibits Bek (FGF receptor) tyrosine kinase and c-kit. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype. It also induces apoptosis in a small-cell lung cancer cell line (H526). AG-1296 is an inhibitor of Tyrosine Kinase. AG-1296 is an inhibitor of PDGFR-alpha and PDGFR-beta.
AG-1296 (CAS 146535-11-7) References
- 5-hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways. | Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 2591-6. PMID: 10688905
- TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). | Strutz, F., et al. 2001. Kidney Int. 59: 579-92. PMID: 11168939
- The role of PDGF receptor inhibitors and PI3-kinase signaling in the pathogenesis of corneal neovascularization. | Dell, S., et al. 2006. Invest Ophthalmol Vis Sci. 47: 1928-37. PMID: 16639000
- Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis. | Melton, AC. and Yee, HF. 2007. Hepatology. 45: 1446-53. PMID: 17465006
- Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor beta. | Shimizu, N., et al. 2008. J Appl Physiol (1985). 104: 766-72. PMID: 18187612
- Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves the antiangiogenic efficacy for advanced stage mouse corneal neovascularization. | Chaoran, Z., et al. 2011. Graefes Arch Clin Exp Ophthalmol. 249: 1493-501. PMID: 21574021
- Fingolimod potentiates the effects of sunitinib malate in a rat breast cancer model. | Mousseau, Y., et al. 2012. Breast Cancer Res Treat. 134: 31-40. PMID: 22160641
- Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo. | Li, H., et al. 2015. Oncol Lett. 10: 3429-3433. PMID: 26788146
- Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors. | Contreras, O., et al. 2019. J Cell Sci. 132: PMID: 31434718
- Small-molecule inhibitor - tyrphostin AG1296 regulates proliferation, survival and migration of rhabdomyosarcoma cells. | Lasota, M., et al. 2021. J Physiol Pharmacol. 72: PMID: 35377340
- Tyrosine kinase inhibition: an approach to drug development. | Levitzki, A. and Gazit, A. 1995. Science. 267: 1782-8. PMID: 7892601
- Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. | Kovalenko, M., et al. 1997. Biochemistry. 36: 6260-9. PMID: 9174341
- Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins. | Krystal, GW., et al. 1997. Cancer Res. 57: 2203-8. PMID: 9187122
Inhibitor of:
Bek, c-Kit, PDGFR-alpha, PDGFR-beta, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG-1296, 5 mg | sc-200631 | 5 mg | $121.00 | |||
AG-1296, 25 mg | sc-200631A | 25 mg | $476.00 |