Molecular structure of AG-1288, CAS Number: 116313-73-6
AG-1288 (CAS 116313-73-6)
Alternate Names:
α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile
Application:
AG-1288 is a tyrosine kinase inhibitor and cell protective agent
CAS Number:
116313-73-6
Purity:
≥98%
Molecular Weight:
231.2
Molecular Formula:
C10H5N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG-1288 is a tyrosine kinase inhibitor. It has been shown in human amnion cells (IC50 =21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity. It has also been reported to protect mice against lipopolysaccharide-induced lethal toxicity. This effect correlates with its ability to block LPS-induced production of nitric oxide in macrophages, and tumor necrosis factor α. AG-1288 is an inhibitor of Guanylate Cyclases.
AG-1288 (CAS 116313-73-6) References
- Detection of increased tyrosine phosphorylation in murine Langerhans cells after stimulation with contact sensitizers. | Neisius, U., et al. 1999. Arch Dermatol Res. 291: 22-7. PMID: 10025724
- Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells. | Kanda, N. 1999. Biochem Biophys Res Commun. 256: 41-4. PMID: 10066419
- Tyrosine kinase inhibitors block the glucocorticoid stimulation of prostaglandin endoperoxide H synthase expression in amnion cells. | Zakar, T., et al. 1999. Can J Physiol Pharmacol. 77: 138-42. PMID: 10535705
- Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. | Jaleel, M., et al. 2004. Biochemistry. 43: 8247-55. PMID: 15209521
- Involvement of iNOS and NO in TNF-alpha-downregulated resistin gene expression in 3T3-L1 adipocytes. | Juan, CC., et al. 2008. Obesity (Silver Spring). 16: 1219-25. PMID: 18369347
- Stimulatory effect of benzylidenemalononitrile tyrphostins on expression of NO-dependent genes in U-937 monocytic cells. | Turpaev, K. and Drapier, JC. 2009. Eur J Pharmacol. 606: 1-8. PMID: 19374863
- Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. | Novogrodsky, A., et al. 1994. Science. 264: 1319-22. PMID: 8191285
- Tumour necrosis factor-alpha-induced ICAM-1 expression in human vascular endothelial and lung epithelial cells: modulation by tyrosine kinase inhibitors. | Burke-Gaffney, A. and Hellewell, PG. 1996. Br J Pharmacol. 119: 1149-58. PMID: 8937718
- Protein tyrosine phosphorylation mediates TNF-induced endothelial-neutrophil adhesion in vitro. | Kelly, SA., et al. 1998. Am J Physiol. 274: H513-9. PMID: 9486255
Inhibitor of:
Guanylate Cyclases, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG-1288, 10 mg | sc-200664 | 10 mg | $59.00 | |||
AG-1288, 50 mg | sc-200664A | 50 mg | $305.00 |