Molecular structure of AG 126, CAS Number: 118409-62-4
AG 126 (CAS 118409-62-4)
See product citations (6)
Alternate Names:
Tyrphostin AG 126
Application:
AG 126 is selectively inhibits phosphorylation of ERK 1 and ERK 2
CAS Number:
118409-62-4
Purity:
98%
Molecular Weight:
215.17
Molecular Formula:
C10H5N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC50 = 15.38 μM).
AG 126 (CAS 118409-62-4) References
- The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat. | Cuzzocrea, S., et al. 2000. Lab Invest. 80: 1439-53. PMID: 11005212
- The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. | Dugo, L., et al. 2002. Intensive Care Med. 28: 775-88. PMID: 12107686
- Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner. | Roifman, CM. and Wang, G. 1992. J Immunol. 149: 1179-84. PMID: 1380035
- Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon. | Moore, BA., et al. 2004. Am J Physiol Gastrointest Liver Physiol. 286: G214-24. PMID: 14512290
- Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. | Kahlenberg, JM. and Dubyak, GR. 2004. Am J Physiol Cell Physiol. 286: C1100-8. PMID: 15075209
- Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. | Angstwurm, K., et al. 2004. Infect Immun. 72: 3294-8. PMID: 15155632
- Aromatic malononitriles stimulate the resistance of insulin-producing beta-cells to oxidants and inflammatory cytokines. | Turpaev, K. and Welsh, N. 2016. Eur J Pharmacol. 784: 69-80. PMID: 27178899
- Exploring the molecular mechanisms of asthma across multiple datasets. | Guo, L., et al. 2024. Ann Med. 56: 2258926. PMID: 38489401
- Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors. | Sármay, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 4140-4. PMID: 8183883
- Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. | Novogrodsky, A., et al. 1994. Science. 264: 1319-22. PMID: 8191285
Inhibitor of:
Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 126, 5 mg | sc-3528 | 5 mg | $94.00 | |||
AG 126, 25 mg | sc-3528A | 25 mg | $372.00 |