Molecular structure of AG 1024, CAS Number: 65678-07-1
AG 1024 (CAS 65678-07-1)
See product citations (22)
Alternate Names:
Tyrphostin AG 1024
Application:
AG 1024 is inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation
CAS Number:
65678-07-1
Purity:
≥98%
Molecular Weight:
305.17
Molecular Formula:
C14H13BrN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AG 1024 selectively inhibits the IGF-1R (insulin-like growth factor 1 receptor). Human breast cancer cell studies report AG 1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG 1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG 1024 decreases Ang II-mediated NAD(P)H oxidase activation. AG 1024 is an inhibitor of insulin R.
AG 1024 (CAS 65678-07-1) References
- Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. | Wen, B., et al. 2001. Br J Cancer. 85: 2017-21. PMID: 11747348
- Vascular smooth muscle cell NAD(P)H oxidase activity during the development of hypertension: Effect of angiotensin II and role of insulinlike growth factor-1 receptor transactivation. | Cruzado, MC., et al. 2005. Am J Hypertens. 18: 81-7. PMID: 15691621
- P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1. | Van Kolen, K., et al. 2006. Cell Signal. 18: 1169-81. PMID: 16236484
- Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. | Zhao, W., et al. 2010. Neurosignals. 18: 236-45. PMID: 21346324
- Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption. | Ilatovskaya, DV., et al. 2015. Am J Physiol Renal Physiol. 308: F713-9. PMID: 25651558
- Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation. | Swetha, M. and Ramaiah, KVA. 2015. Arch Biochem Biophys. 585: 98-108. PMID: 26321373
- Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer. | Park, JH., et al. 2016. Oncotarget. 7: 22005-15. PMID: 26980747
- Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients. | Ito, S., et al. 2016. Neurochem Int. 101: 22-29. PMID: 27693452
- Genistein and AG1024 synergistically increase the radiosensitivity of prostate cancer cells. | Tang, Q., et al. 2018. Oncol Rep. 40: 579-588. PMID: 29901146
- AG-1024 Sensitizes Sorafenib-Resistant Hepatocellular Carcinoma Cells to Sorafenib via Enhancing G1/S Arrest. | Zhou, W., et al. 2021. Onco Targets Ther. 14: 1049-1059. PMID: 33623392
- Triptolide prevents LPS-induced skeletal muscle atrophy via inhibiting NF-κB/TNF-α and regulating protein synthesis/degradation pathway. | Fang, WY., et al. 2021. Br J Pharmacol. 178: 2998-3016. PMID: 33788266
- Tyrphostin AG1024 downregulates aryl hydrocarbon receptor (AhR) expression in an IGF1R and IR-independent manner. | Tomita, S., et al. 2022. Toxicol Lett. 360: 62-70. PMID: 35149128
- Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. | Yang, CW., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35215353
- AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway. | Liu, J., et al. 2023. Open Med (Wars). 18: 20230683. PMID: 37034500
- Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. | Párrizas, M., et al. 1997. Endocrinology. 138: 1427-33. PMID: 9075698
Inhibitor of:
A2LD1, BC055107, BCLP, BZW1, CEACAM1, Daf2, IGF-I, IGF-IA, IGF-IB, IGF-II, IGF-IIR, IGF-IR, IGF-IRα, IGF-IRβ, IGFBP1, IGFBP3, IGFBPL1, IGFL2, INSL4, insulin R, IRS-2, IRS-4, neuroligin X/Y, PGRMC1, Ribosomal Protein L22, Ribosome (RPL; 40S; 60S), SH-PTP2, and Tyrosine Kinase.Activator of:
Ksr-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 1024, 1 mg | sc-205907 | 1 mg | $105.00 |