Date published: 2025-12-5

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AG 045572 (CAS 263847-55-8)

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Alternate Names:
5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide
Application:
AG 045572 is a selective GnRHR (gonadotropin-releasing hormone receptor) antagonist
CAS Number:
263847-55-8
Purity:
≥97%
Molecular Weight:
491.62
Molecular Formula:
C30H37NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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AG 045572, an organic compound characterized by a five-membered ring comprising four carbon atoms and one oxygen atom, has gained significant prominence in scientific research due to its distinctive properties and wide-ranging applications. This versatile compound has found extensive utilization in various scientific studies, primarily owing to its role as a fundamental building block in the synthesis of diverse organic compounds. Furthermore, the employment of AG 045572 as a ligand in coordination chemistry holds substantial significance in the realm of catalyst and material development. Moreover, researchers have leveraged AG 045572 as a valuable probe to explore and elucidate the binding interactions between proteins and ligands. Its mechanism of action is contingent upon the specific target it engages. For instance, studies have revealed AG 045572′s ability to inhibit the activity of specific enzymes such as acetylcholinesterase and tyrosinase. Additionally, it has demonstrated binding affinity towards certain receptors like the adenosine receptor. Moreover, AG 045572 has showcased its capability to intercalate into DNA, thereby exerting influence over its structure and function.


AG 045572 (CAS 263847-55-8) References

  1. Effect of testosterone suppression on the pharmacokinetics of a potent gnRH receptor antagonist.  |  Iatsimirskaia, EA., et al. 2002. Pharm Res. 19: 202-8. PMID: 11883648
  2. Effect of gonadectomy and hormones on sex differences in ketoprofen enantiomer glucuronidation and renal excretion of formed glucuronides in the rat.  |  Palylyk-Colwell, EL. and Jamali, F. 2004. Pharm Res. 21: 989-95. PMID: 15212164
  3. Non-peptide gonadotropin-releasing hormone receptor antagonists.  |  Betz, SF., et al. 2008. J Med Chem. 51: 3331-48. PMID: 18419112
  4. Silicon analogues of the nonpeptidic GnRH antagonist AG-045572: syntheses, crystal structure analyses, and pharmacological characterization.  |  Barnes, MJ., et al. 2011. ChemMedChem. 6: 2070-80. PMID: 21953839

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

AG 045572, 1 mg

sc-203499
1 mg
$107.00