Molecular structure of AFMK, CAS Number: 52450-38-1
AFMK (CAS 52450-38-1)
Alternate Names:
N-[3-[2-(formylamino)-5-methoxyphenyl]-3-oxypropyl]-acetamide; NSC 688263
Application:
AFMK is an immunomodulatory antioxidant melatonin metabolite
CAS Number:
52450-38-1
Purity:
>98%
Molecular Weight:
264.28
Molecular Formula:
C13H16N2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AFMK is a metabolite of the pineal hormone melatonin that exhibits antioxidant, immunomodulatory and anti-inflammatory properties. AFMK was first detected in rat brain and was found to be useful as an index for melatonin synthesis and metabolism.
AFMK (CAS 52450-38-1) References
- Radioimmunoassay of N-acetyl-N-formyl-5-methoxykynuramine (AFMK): a melatonin oxidative metabolite. | Harthé, C., et al. 2003. Life Sci. 73: 1587-97. PMID: 12865098
- Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release. | Silva, SO., et al. 2004. J Neuroimmunol. 156: 146-52. PMID: 15465605
- AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. | Manda, K., et al. 2007. J Pineal Res. 42: 386-93. PMID: 17439555
- Optimized synthesis of the melatonin metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK). | Ximenes, VF. 2008. J Pineal Res. 45: 297-301. PMID: 18373552
- Space radiation-induced inhibition of neurogenesis in the hippocampal dentate gyrus and memory impairment in mice: ameliorative potential of the melatonin metabolite, AFMK. | Manda, K., et al. 2008. J Pineal Res. 45: 430-8. PMID: 18631288
- On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. | Galano, A., et al. 2013. J Pineal Res. 54: 245-57. PMID: 22998574
- Melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), attenuates acute pancreatitis in the rat: in vivo and in vitro studies. | Jaworek, J., et al. 2016. J Physiol Pharmacol. 67: 411-21. PMID: 27512002
- Taxon- and Site-Specific Melatonin Catabolism. | Hardeland, R. 2017. Molecules. 22: PMID: 29160833
- Melatonin and its metabolite N1-acetyl-N2-formyl-5-methoxykynuramine (afmk) enhance chemosensitivity to gemcitabine in pancreatic carcinoma cells (PANC-1). | Leja-Szpak, A., et al. 2018. Pharmacol Rep. 70: 1079-1088. PMID: 30308458
- Protective stabilization of mitochondrial permeability transition and mitochondrial oxidation during mitochondrial Ca2+ stress by melatonin's cascade metabolites C3-OHM and AFMK in RBA1 astrocytes. | Jou, MJ., et al. 2019. J Pineal Res. 66: e12538. PMID: 30415481
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AFMK, 1 mg | sc-205201 | 1 mg | $54.00 | |||
AFMK, 5 mg | sc-205201A | 5 mg | $144.00 | |||
AFMK, 10 mg | sc-205201B | 10 mg | $216.00 | |||
AFMK, 50 mg | sc-205201C | 50 mg | $720.00 |