Molecular structure of AEG 3482, CAS Number: 63735-71-7
AEG 3482 (CAS 63735-71-7)
Alternate Names:
6-Phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
Application:
AEG 3482 is an inhibitor of JNK and an activator of HSF1
CAS Number:
63735-71-7
Molecular Weight:
280.3
Molecular Formula:
C10H8N4O2S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AEG 3482 is a cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. AEG 3482 has been shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 μM).
AEG 3482 (CAS 63735-71-7) References
Salehi, A.H., et al. 2006. Chem. Biol. 13, 213.Inhibitor of:
JNK, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AEG 3482, 5 mg | sc-202911 | 5 mg | $112.00 |