ADP-HPD ammonium salt dihydrate
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ADP-HPD ammonium salt dihydrate serves as a potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG), with a pronounced selectivity exhibited by its inhibitory concentration (IC50) at 120nM, contrasted against a significantly less effective IC50 of 120µM for ADP-ribose. This selectivity underscores its utility in biochemical research, particularly in studying the dynamics of post-translational modifications involving ADP-ribosylation processes. ADP-HPD ammonium salt dihydrate is distinctively characterized by its lack of impact on other related enzymes such as PARP-1 or NAD:arginine mono(ADP-ribosyl)-transferase A, even at high concentrations up to 1mM. This attribute enhances its role in the precise investigation of PARG′s unique enzymatic activities and its contribution to understanding the regulation and function of poly(ADP-ribose) in various cellular processes, providing valuable insights into the non-redundant roles of PARG within the cellular machinery.
ADP-HPD ammonium salt dihydrate References
- A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage. | Vispe, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 9886-91. PMID: 10944198
- Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. | Tucker, JA., et al. 2012. PLoS One. 7: e50889. PMID: 23251397
- Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling. | Smeenk, G., et al. 2013. J Cell Sci. 126: 889-903. PMID: 23264744
- MORC2 regulates DNA damage response through a PARP1-dependent pathway. | Zhang, L. and Li, DQ. 2019. Nucleic Acids Res. 47: 8502-8520. PMID: 31616951
- PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage. | Ahmed, W. and Lingner, J. 2020. Cell Rep. 33: 108347. PMID: 33147465
- Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol. | Slama, JT., et al. 1995. J Med Chem. 38: 389-93. PMID: 7830282
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADP-HPD ammonium salt dihydrate, 60 µg | sc-205927 | 60 µg | $295.00 |