Molecular structure of Adenylyl Cyclase Type V Inhibitor, NKY80, CAS Number: 299442-43-6
Adenylyl Cyclase Type V Inhibitor, NKY80 (CAS 299442-43-6)
Alternate Names:
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Application:
Adenylyl Cyclase Type V Inhibitor, NKY80 is an A cyclase III and V inhibitor
CAS Number:
299442-43-6
Purity:
≥97%
Molecular Weight:
229.2
Molecular Formula:
C12H11N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adenylyl Cyclase Type V Inhibitor, NKY80 is a cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of A cyclase V (adenylyl cyclase (AC) type V isoform) (IC50 = 8.3 muM, 132 muM and 1.7 mM for type V, III and II, respectively) in the presence of Gsalpha GTPgammaS-Forskolin. The compound displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition observed is non-competitive with respect to ATP and Forskolin. Adenylyl Cyclase Type V Inhibitor, NKY80 regulates the AC catalytic activity in heart and lung tissues.
Adenylyl Cyclase Type V Inhibitor, NKY80 (CAS 299442-43-6) References
- Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. | Onda, T., et al. 2001. J Biol Chem. 276: 47785-93. PMID: 11602596
- Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. | Ortiz-Capisano, MC., et al. 2007. Hypertension. 49: 618-24. PMID: 17190869
- Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. | Harney, JA. and Rodgers, RL. 2008. Am J Physiol Endocrinol Metab. 295: E155-61. PMID: 18492769
- Up-regulation of circulating hemocyte population in response to bacterial challenge is mediated by octopamine and 5-hydroxytryptamine via Rac1 signal in Spodoptera exigua. | Kim, GS. and Kim, Y. 2010. J Insect Physiol. 56: 559-66. PMID: 19961854
- L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata. | Rangel-Barajas, C., et al. 2011. Neurobiol Dis. 41: 51-61. PMID: 20736067
- Similarly potent inhibition of adenylyl cyclase by P-site inhibitors in hearts from wild type and AC5 knockout mice. | Braeunig, JH., et al. 2013. PLoS One. 8: e68009. PMID: 23840883
- Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. | Brand, CS., et al. 2013. J Pharmacol Exp Ther. 347: 265-75. PMID: 24006339
- Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats. | Bräunig, JH., et al. 2014. Naunyn Schmiedebergs Arch Pharmacol. 387: 389-98. PMID: 24276219
- Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors. | Klotz, KN. and Kachler, S. 2016. Naunyn Schmiedebergs Arch Pharmacol. 389: 349-52. PMID: 26660072
Inhibitor of:
A cyclase III, and A cyclase V.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenylyl Cyclase Type V Inhibitor, NKY80, 5 mg | sc-221217 | 5 mg | $122.00 | |||
Adenylyl Cyclase Type V Inhibitor, NKY80, 25 mg | sc-221217A | 25 mg | $423.00 |