Molecular structure of Adenylosuccinic acid, CAS Number: 19046-78-7
Adenylosuccinic acid (CAS 19046-78-7)
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Alternate Names:
Adenylosuccinic acid is also known as Aspartyl adenylate.
Application:
Adenylosuccinic acid is a purine ribonucleoside monophosphate. consisting of a purine base linked to a ribose with one monophosphate group.
CAS Number:
19046-78-7
Molecular Weight:
463.29
Molecular Formula:
C14H18N5O11P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adenylosuccinic acid belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Adenylosuccinic acid has a protective effect on mdx skeletal muscles, and can increase mitochondrial viability in mdx flexor digitorum brevis fibres. It participates in a number of enzymatic reactions. It is involved in the aspartate metabolism pathway, the mercaptopurine action pathway, the azathioprine action pathway, and the purine metabolism pathway. Adenylosuccinic acid is also known as Aspartyl adenylate, Succinyl AMP, adenylosuccinate, and 2-[9-(3,4-dihydroxy-5-phosphonooxymethyl-tetrahydro-furan-2-yl)-9h-purin-6-ylamino]-succinic acid.
Adenylosuccinic acid (CAS 19046-78-7) References
- Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. IV. Isolation of a mutant which accumulates adenylosuccinic acid and succinylaminoimidazole carboxamide ribotide. | Patterson, D. 1976. Somatic Cell Genet. 2: 189-203. PMID: 1028168
- Screening for adenylosuccinate lyase deficiency: clinical, biochemical and molecular findings in four patients. | Castro, M., et al. 2002. Neuropediatrics. 33: 186-9. PMID: 12368987
- Adenylosuccinate lyase of Schistosoma mansoni: gene structure, mRNA expression, and analysis of the predicted peptide structure of a potential chemotherapeutic target. | Foulk, BW., et al. 2002. Int J Parasitol. 32: 1487-95. PMID: 12392914
- REINVESTIGATION OF BOVINE LIVER NUCLEOTIDE-PEPTIDE AND SEPARATION OF ADENYLOSUCCINIC ACID (6-SUCCINOAMINOPURINE-9-RIBOSYL-5'-PHOSPHATE). | OKUHARA, E. and HANSEN, RG. 1964. J Biochem. 55: 287-92. PMID: 14162510
- HADACIDIN POTENTIATION OF LETHAL ACTION OF IONIZING IRRADIATION. II. EFFECT ON PROLIFERATING GRAM-NEGATIVE BACTERIA. | PITTILLO, RF. and MONCRIEF, FC. 1965. Proc Soc Exp Biol Med. 118: 525-9. PMID: 14268674
- A mild form of adenylosuccinate lyase deficiency in absence of typical brain MRI features diagnosed by whole exome sequencing. | Macchiaiolo, M., et al. 2017. Ital J Pediatr. 43: 65. PMID: 28768552
- Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability. | Tewari, SG., et al. 2019. Malar J. 18: 86. PMID: 30890151
- Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy. | Timpani, CA., et al. 2020. Sci Rep. 10: 1125. PMID: 31980663
- Adenylosuccinic acid: a novel inducer of the cytoprotectant Nrf2 with efficacy in Duchenne muscular dystrophy. | Rybalka, E., et al. 2021. Curr Med Res Opin. 37: 465-467. PMID: 33331789
- A Study on Gentiana dahurica Fisch Ethanol Extract Alleviating Alcoholic Liver Disease in Mice: A Metabolomic Analysis of the Liver. | Cao, H., et al. 2021. Evid Based Complement Alternat Med. 2021: 5569538. PMID: 34257684
- Comparative Analysis of the Composition of Fatty Acids and Metabolites between Black Tibetan and Chaka Sheep on the Qinghai-Tibet Plateau. | Guo, T., et al. 2022. Animals (Basel). 12: PMID: 36290131
- Incorporation of adenosine-8-14/C and inosine-8-14C into rabbit heart adenine nucleotides. | Liu, MS. and Feinberg, H. 1971. Am J Physiol. 220: 1242-8. PMID: 5556737
- Determinants of the toxicity of L-alanosine to various organs of the mouse. | Tyagi, AK., et al. 1981. Toxicology. 21: 59-69. PMID: 7281196
- Investigation of isoenzymes of adenylosuccinase in human blood cells. | Pagani, R., et al. 1998. Adv Exp Med Biol. 431: 629-32. PMID: 9598141
Activator of:
NARS2.Substrate of:
Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenylosuccinic acid, 25 mg | sc-214511 | 25 mg | $240.00 | |||
Adenylosuccinic acid, 100 mg | sc-214511A | 100 mg | $800.00 | |||
Adenylosuccinic acid, 500 mg | sc-214511B | 500 mg | $4000.00 |