Adenosine Kinase Inhibitor CAS: 214697-26-4
MF: C22H19BrN6O•2HCl
MW: 536.3
A cell-permeable compound that acts as a potent adenosine kinase inhibitor.

Adenosine Kinase Inhibitor (CAS 214697-26-4)

Adenosine Kinase Inhibitor | CAS 214697-26-4 is rated 5.0 out of 5 by 1.
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Synonym: ABT-702; 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine
Application: A cell-permeable compound that acts as a potent adenosine kinase inhibitor
CAS Number: 214697-26-4
Purity: ≥90%
Molecular Weight: 536.3
Molecular Formula: C22H19BrN6O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Adenosine Kinase Inhibitor is a cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible ADK (adenosine kinase (AK)) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors.

Physical State :
Solid
Solubility :
Soluble in DMSO (24 mg/ml). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
227-245° C (lit.)
IC50 :
placental AK: IC50 = 1.5 nM (human); brain cytosolic AK: IC50 = 1.7 nM (rat); ADK: IC50 = 50.7 nM (IMR-32 cells)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760265
MDL Number :
MFCD03452809
SMILES :
C1COCCN1C2=NC=C(C=C2)C3=NC4=C(C(=C3)C5=CC(=CC=C5)Br)C(=NC=N4)N.Cl.Cl

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Certificate of Analysis

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Adenosine Kinase Inhibitor  Product Citations

See how others have used Adenosine Kinase Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 25103241  Mello, Pde A. et al. 2014. Mol. Biol. Cell. 25: 2905-18.

PMID: # 24841126  Pye, C. et al. 2014. Pharmacol. Res. 85: 45-54.

PMID: # 23770229  Elsherbiny, NM. et al. 2013. Life Sci. 93: 78-88.

PMID: # 31194978  Exp. Cell Res. 382: 111456.

PMID: # 29305710  J. Cancer Res. Clin. Oncol. 144: 469-482.

PMID: # 30995110  Am. J. Physiol. Renal Physiol. 317: F107-F115.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Otsuguro Otsuguro, et al. (PubMed ID 26066576) found that ABT-y02 (Adenosine Kinase Inhibitor) inhibits spinal nociceptive transmission by adenisine release (rat model used). -SCBT Publication Review
Date published: 2015-02-19
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