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Adenosine Kinase Inhibitor is a cell-permeable, non-nucleoside pyridopyrimidine compound that acts as a potent, adenosine-competitive, and reversible ADK (adenosine kinase (AK)) inhibitor (IC50 = 50.7 nM using intact IMR-32 cells and 1.7 nM in cell-free assays using rat brain cytosolic AK). The inhibitory effect is not species-specific and its pharmacological selectivity is confirmed using a panel of more than 80 other enzymes, ion channels, and receptors, including various adesine receptors.
See how others have used Adenosine Kinase Inhibitor. Click on the entry to view the PubMed entry .
PMID: # 25103241 Mello, Pde A. et al. 2014. Mol. Biol. Cell. 25: 2905-18.
PMID: # 24841126 Pye, C. et al. 2014. Pharmacol. Res. 85: 45-54.
PMID: # 23770229 Elsherbiny, NM. et al. 2013. Life Sci. 93: 78-88.
PMID: # 31194978 Exp. Cell Res. 382: 111456.
PMID: # 29305710 J. Cancer Res. Clin. Oncol. 144: 469-482.
PMID: # 30995110 Am. J. Physiol. Renal Physiol. 317: F107-F115.
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