Molecular structure of Adenosine Amine Congener, CAS Number: 96760-69-9
Adenosine Amine Congener (CAS 96760-69-9)
Alternate Names:
N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2- oxoethyl]phenyl]adenosine
Application:
Adenosine Amine Congener is an aqueous-soluble Adenosine A1-R agonist
CAS Number:
96760-69-9
Molecular Weight:
576.60
Molecular Formula:
C28H32N8O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Shown to be an aqueous-soluble adenosine receptor A1 agonist.
Adenosine Amine Congener (CAS 96760-69-9) References
- Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. | Von Lubitz, DK., et al. 1999. Eur J Pharmacol. 369: 313-7. PMID: 10225368
- Adenosine A(1) receptor agonism in the immature rat brain and heart. | Adén, U., et al. 2001. Eur J Pharmacol. 426: 185-92. PMID: 11527543
- Lack of central effects of peripherally administered adenosine A(1) agonists on synaptic transmission in the rat hippocampus. | Gervitz, LM., et al. 2002. Brain Res. 951: 141-5. PMID: 12231468
- The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. | Blum, D., et al. 2002. J Neurosci. 22: 9122-33. PMID: 12388620
- A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. | Tsutsui, S., et al. 2004. J Neurosci. 24: 1521-9. PMID: 14960625
- Effects of adenosine and ATP on the membrane potential and synaptic transmission in neurons of the rat locus coeruleus. | Kuwahata, T. 2004. Kurume Med J. 51: 109-23. PMID: 15373228
- Differential effects of the adenosine A1 receptor agonist adenosine amine congener on renal, femoral and carotid vascular conductance in preterm fetal sheep. | Booth, LC., et al. 2008. Clin Exp Pharmacol Physiol. 35: 1316-20. PMID: 18671718
- Adenosine amine congener mitigates noise-induced cochlear injury. | Vlajkovic, SM., et al. 2010. Purinergic Signal. 6: 273-81. PMID: 20806018
- Adenosine amine congener as a cochlear rescue agent. | Vlajkovic, SM., et al. 2014. Biomed Res Int. 2014: 841489. PMID: 25243188
- Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration. | Chang, H., et al. 2017. Biomed Res Int. 2017: 8091462. PMID: 28194422
- Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival. | Lin, SCY., et al. 2019. Front Cell Neurosci. 13: 207. PMID: 31156393
- Adenosine analogs with covalently attached lipids have enhanced potency at A1-adenosine receptors. | Jacobson, KA., et al. 1987. FEBS Lett. 225: 97-102. PMID: 3691809
- Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist. | Von Lubitz, DK., et al. 1996. Eur J Pharmacol. 302: 43-8. PMID: 8790990
- Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. | Von Lubitz, DK., et al. 1996. Eur J Pharmacol. 316: 171-9. PMID: 8982684
- A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. | Stambaugh, K., et al. 1997. Am J Physiol. 273: H501-5. PMID: 9249524
Activator of:
Adenosine A Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine Amine Congener, 5 mg | sc-291843 | 5 mg | $428.00 | |||
Adenosine Amine Congener, 10 mg | sc-291843A | 10 mg | $712.00 |