Adenosine A2A-R Antibody (7F6-G5-A2): sc-32261

Adenosine A2A-R Antibody (7F6-G5-A2) is a mouse monoclonal IgG2a kappa light chain antibody that detects Adenosine A2A-R protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-Adenosine A2A-R antibody (7F6-G5-A2) comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. Adenosine A2A receptor resides primarily on cell surfaces, playing a crucial role in adenosine signaling pathways that regulate coronary vasodilation and neurotransmitter release. Located strategically on the cell membrane, Adenosine A2A-R responds quickly to changes in extracellular adenosine levels, influencing cardiovascular function and neuroprotection. Adenosine A2A-R interacts with G proteins for signal transduction and partners with other receptors to maintain cellular homeostasis and stress response. Research into Adenosine A2A-R function and interactions continues to drive development of new treatments for cardiovascular diseases and neurodegenerative disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Adenosine A2A-R Antibody (7F6-G5-A2) References:

1. Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies.  |  Koshiba, M., et al. 1999. Mol Pharmacol. 55: 614-24. PMID: 10051547
2. Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum.  |  Hettinger, BD., et al. 2001. J Comp Neurol. 431: 331-46. PMID: 11170009
3. Molecular characterization of a human brain adenosine A2 receptor.  |  Furlong, TJ., et al. 1992. Brain Res Mol Brain Res. 15: 62-6. PMID: 1331670
4. Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function.  |  Rosin, DL., et al. 2003. Neurology. 61: S12-8. PMID: 14663003
5. Cloning and expression of an A1 adenosine receptor from rat brain.  |  Mahan, LC., et al. 1991. Mol Pharmacol. 40: 1-7. PMID: 1857334
6. Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy.  |  Liu, Y., et al. 2022. Adv Sci (Weinh). 9: e2104182. PMID: 35306759
7. [Blocking Adenosine/A2AR Pathway for Cancer Therapy].  |  Liu, J., et al. 2022. Zhongguo Fei Ai Za Zhi. 25: 460-467. PMID: 35899442
8. Adenosine A2AR in viral immune evasion and therapy: unveiling new avenues for treating COVID-19 and AIDS.  |  Atif, M., et al. 2024. Mol Biol Rep. 51: 894. PMID: 39115571
9. Molecular cloning and characterization of the human A3 adenosine receptor.  |  Salvatore, CA., et al. 1993. Proc Natl Acad Sci U S A. 90: 10365-9. PMID: 8234299
10. The A2A adenosine receptor mediates coronary vasodilation.  |  Belardinelli, L., et al. 1998. J Pharmacol Exp Ther. 284: 1066-73. PMID: 9495868
11. Ca2+ dependence of the response of three adenosine type receptors in rat hepatocytes.  |  Guinzberg, R., et al. 1997. Eur J Pharmacol. 340: 243-7. PMID: 9580059
12. Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system.  |  Rosin, DL., et al. 1998. J Comp Neurol. 401: 163-86. PMID: 9822147

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adenosine A2A-R Antibody (7F6-G5-A2) has 49 citations in a variety of scientific publications.

Primary antibodies like Anti-Adenosine A2A-R Antibody (7F6-G5-A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adenosine A2A-R Antibody (7F6-G5-A2) Specifications

Alternate Product Name: ADORA2A

Product Clone Name: 7F6-G5-A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Adenosine A2A-R

Epitope Species: human

Product Reactivity/Detection: Adenosine A2A-R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 49 citations in various scientific publications

Available Conjugates/Forms for Adenosine A2A-R Antibody (7F6-G5-A2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, PerCP: Peridinin Chlorophyll Protein Complex with Cyanin-5.5