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Adenosine 5′-O-(2-Thiodiphosphate), Trilithium Salt (CAS 73536-95-5)

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Application:
Adenosine 5′-O-(2-Thiodiphosphate), Trilithium Salt is a P2-purinergic receptor agonist
CAS Number:
73536-95-5
Molecular Weight:
461.0
Molecular Formula:
C10H12Li3N5O9P2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Adenosine 5′-O-(2-Thiodiphosphate), trilithium salt is a substrate and inhibitor of ADP-dependent enzyme systems. A P2-purinergic receptor agonist that acts as a potent insulin secretagogue.


Adenosine 5′-O-(2-Thiodiphosphate), Trilithium Salt (CAS 73536-95-5) References

  1. Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adnosine 5-diphosphate (ADP) in human platelets.  |  Park, HS. and Hourani, SM. 1999. Br J Pharmacol. 127: 1359-66. PMID: 10455285
  2. Characterization of P2X3, P2Y1 and P2Y4 receptors in cultured HEK293-hP2X3 cells and their inhibition by ethanol and trichloroethanol.  |  Fischer, W., et al. 2003. J Neurochem. 85: 779-90. PMID: 12694404
  3. Adenosine-5'-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas.  |  Bertrand, G., et al. 1991. Br J Pharmacol. 102: 627-30. PMID: 1364829
  4. Evidence for the existence of P2Y1,2,4 receptor subtypes in HEK-293 cells: reactivation of P2Y1 receptors after repetitive agonist application.  |  Fischer, W., et al. 2005. Naunyn Schmiedebergs Arch Pharmacol. 371: 466-72. PMID: 16025270
  5. Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.  |  Gerevich, Z., et al. 2005. Eur J Pharmacol. 521: 34-8. PMID: 16181623
  6. ATP reduces gel compaction in osteoblast-populated collagen gels.  |  Qi, J., et al. 2007. J Appl Physiol (1985). 102: 1152-60. PMID: 17122380
  7. P2-, but not P1-purinoceptors mediate formation of 1, 4, 5-inositol trisphosphate and its metabolites via a pertussis toxin-insensitive pathway in the rat renal cortex.  |  Nanoff, C., et al. 1990. Br J Pharmacol. 100: 63-8. PMID: 2115389
  8. Purinergic modulation of norepinephrine release and uptake in rat brain cortex: contribution of glial cells.  |  Pinho, D., et al. 2013. J Neurophysiol. 110: 2580-91. PMID: 24027106
  9. The effects of magnesium upon adenosine triphosphate-sensitive potassium channels in a rat insulin-secreting cell line.  |  Findlay, I. 1987. J Physiol. 391: 611-29. PMID: 2451014
  10. Potentiation of adenosine triphosphate-induced contractile responses of the guinea-pig isolated vas deferens by adenosine monophosphate and adenosine 5'-monophosphorothioate.  |  Fedan, JS. 1987. Br J Pharmacol. 91: 633-9. PMID: 3038248
  11. Comparison of effects of inhibitors on adenosine triphosphatase and adenosine diphosphatase activities in rat-liver mitochondria.  |  Montague, DJ., et al. 1984. Eur J Biochem. 139: 529-34. PMID: 6321179
  12. Effects of divalent cations on the potency of ATP and related agonists in the rat isolated vagus nerve: implications for P2 purinoceptor classification.  |  Trezise, DJ., et al. 1994. Br J Pharmacol. 113: 463-70. PMID: 7834197
  13. Stimulation of insulin secretion and improvement of glucose tolerance in rat and dog by the P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate).  |  Hillaire-Buys, D., et al. 1993. Br J Pharmacol. 109: 183-7. PMID: 8495239
  14. Coexistence of purino- and pyrimidinoceptors on activated rat microglial cells.  |  Nörenberg, W., et al. 1997. Br J Pharmacol. 121: 1087-98. PMID: 9249243
  15. Involvement of K+ channel permeability changes in the L-NAME and indomethacin resistant part of adenosine-5'-O-(2-thiodiphosphate)-induced relaxation of pancreatic vascular bed.  |  Hillaire-Buys, D., et al. 1998. Br J Pharmacol. 124: 149-56. PMID: 9630354

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Adenosine 5′-O-(2-Thiodiphosphate), Trilithium Salt, 25 mg

sc-203804
25 mg
$772.00