Date published: 2026-5-24

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Adenosine 5′-Diphosphate disodium salt (CAS 16178-48-6)

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Alternate Names:
5′-ADP-Na2
Application:
CAS Number:
16178-48-6
Purity:
>95%
Molecular Weight:
471.16
Molecular Formula:
C10H13N5O10P22Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Adenosine 5′-diphosphate (ADP) disodium salt is a pivotal biochemical agent primarily involved in the transfer and storage of energy within cells. This compound plays a critical role in cellular processes by participating in the synthesis of ATP (adenosine triphosphate) through both the glycolytic pathway and the mitochondrial oxidative phosphorylation. As a key intermediate in metabolism, Adenosine 5′-diphosphate disodium salt acts as a signaling molecule that regulates platelet aggregation and is integral to the purinergic signaling pathways, which are essential for cellular communication. In research, Adenosine 5′-diphosphate disodium salt is extensively used to study enzyme kinetics, especially in assays involving kinases and ATPases, due to its ability to donate phosphate groups. It is also employed in investigations related to the cellular energy status, mechanisms of cellular signaling, and the elucidation of metabolic pathways. Its role extends to the exploration of energy transfer processes and the understanding of the molecular basis of energy conservation and utilization in biological systems.


Adenosine 5′-Diphosphate disodium salt (CAS 16178-48-6) References

  1. Interaction centres of purine nucleotides: adenosine-5'-diphosphate and adenosine-5'-triphosphate in their reactions with tetramines and Cu(II) ions.  |  Gasowska, A. 2003. J Inorg Biochem. 96: 346-56. PMID: 12888270
  2. Intracellular adenosine 5'-triphosphate, adenosine 5'-diphosphate, and adenosine 5'-monophosphate detection by short-end injection capillary electrophoresis using methylcellulose as the effective electroosmostic flow suppressor.  |  Zinellu, A., et al. 2008. Electrophoresis. 29: 3069-73. PMID: 18551716
  3. Hexokinase inhibitor screening based on adenosine 5'-diphosphate determination by electrophoretically mediated microanalysis.  |  Wang, T. and Kang, J. 2009. Electrophoresis. 30: 1349-54. PMID: 19306267
  4. Online cleanup of accelerated solvent extractions for determination of adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and adenosine 5'-monophosphate (AMP) in royal jelly using high-performance liquid chromatography.  |  Xue, X., et al. 2009. J Agric Food Chem. 57: 4500-5. PMID: 19435312
  5. Ultra-fast adenosine 5'-triphosphate, adenosine 5'-diphosphate and adenosine 5'-monophosphate detection by pressure-assisted capillary electrophoresis UV detection.  |  Zinellu, A., et al. 2010. Electrophoresis. 31: 2854-7. PMID: 20661945
  6. Increased intravitreal adenosine 5'-triphosphate, adenosine 5'-diphosphate and adenosine 5'-monophosphate levels in patients with proliferative diabetic retinopathy.  |  Loukovaara, S., et al. 2015. Acta Ophthalmol. 93: 67-73. PMID: 25079888
  7. Defective platelet autocrine signaling in HPS.  |  Storrie, B. 2015. Blood. 125: 1515-6. PMID: 25745182
  8. The Molecular Mechanism of P2Y1 Receptor Activation.  |  Yuan, S., et al. 2016. Angew Chem Int Ed Engl. 55: 10331-5. PMID: 27460867
  9. An easy and fast adenosine 5'-diphosphate quantification procedure based on hydrophilic interaction liquid chromatography-high resolution tandem mass spectrometry for determination of the in vitro adenosine 5'-triphosphatase activity of the human breast cancer resistance protein ABCG2.  |  Wagmann, L., et al. 2017. J Chromatogr A. 1521: 123-130. PMID: 28951049
  10. Clopidogrel Partially Counteracts Adenosine-5'-Diphosphate Effects on Blood Pressure and Renal Hemodynamics and Excretion in Rats.  |  Roszkowska-Chojecka, MM., et al. 2018. Am J Med Sci. 356: 287-295. PMID: 30293555
  11. A Fluorescence Sensor Array Based on Zinc(II)-Carboxyamidoquinolines: Toward Quantitative Detection of ATP*.  |  Pushina, M., et al. 2021. Chemistry. 27: 11344-11351. PMID: 34129701
  12. Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.  |  Furuike, Y., et al. 2022. Sci Adv. 8: eabm8990. PMID: 35427168
  13. Gas-Phase Internal Ribose Residue Loss from Mg-ATP and Mg-ADP Complexes: Experimental and Theoretical Evidence for Phosphate-Mg-Adenine Interaction.  |  Frańska, M., et al. 2022. J Am Soc Mass Spectrom. 33: 1474-1479. PMID: 35796751
  14. Extracellular adenosine 5'-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes.  |  Yokota, S., et al. 2023. Mol Biol Rep. 50: 1595-1602. PMID: 36526849

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Adenosine 5′-Diphosphate disodium salt, 500 mg

sc-202442B
500 mg
$28.00

Adenosine 5′-Diphosphate disodium salt, 1 g

sc-202442
1 g
$60.00

Adenosine 5′-Diphosphate disodium salt, 5 g

sc-202442A
5 g
$216.00

Adenosine 5′-Diphosphate disodium salt, 25 g

sc-202442C
25 g
$485.00

Adenosine 5′-Diphosphate disodium salt, 50 g

sc-202442D
50 g
$787.00

Adenosine 5′-Diphosphate disodium salt, 100 g

sc-202442E
100 g
$1275.00

Adenosine 5′-Diphosphate disodium salt, 250 g

sc-202442F
250 g
$3127.00