Molecular structure of Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt
Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt
Application:
Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt is a cAMP-dependent protein kinase activator
Molecular Weight:
446.1
Molecular Formula:
C10H10BrN5O5PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt is a potent cell-permeable, metabolically-stable activator of cAMP-dependent protein kinase (PKA). Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt induces guanine nucleotide exchange factor activity of GEFI (Epac) and GEFII towards Rap1 both in vivo and in vitro. The compound is more lipophilic and cell-permeable compared to Sp-cAMPS.
Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt References
- Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum. | Tzavara, ET., et al. 2000. Eur J Neurosci. 12: 1038-46. PMID: 10762335
- Cyclic AMP and mitogen-activated protein kinases are required for glutamate-dependent cyclic AMP response element binding protein and Elk-1 phosphorylation in the dorsal striatum in vivo. | Choe, ES. and McGinty, JF. 2001. J Neurochem. 76: 401-12. PMID: 11208903
- Imaging of calcineurin activated by long-term depression-inducing synaptic inputs in living neurons of rat visual cortex. | Yasuda, H., et al. 2003. Eur J Neurosci. 17: 287-97. PMID: 12542665
- Lipopolysaccharide-induced sensitization of adenylyl cyclase activity in murine macrophages. | Osawa, Y., et al. 2006. Am J Physiol Cell Physiol. 290: C143-51. PMID: 16120652
- Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination. | Garcia, N., et al. 2019. Cells. 8: PMID: 31652775
- PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development. | Garcia, N., et al. 2021. Cells. 10: PMID: 34199823
- Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. | Garcia, N., et al. 2022. Mol Neurobiol. 59: 4044-4064. PMID: 35474562
Activator of:
Epac, and PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine 3′,5′-cyclic Monophosphorothioate,8-Bromo-, Sp-Isomer,Sodium Salt, 5 µmol | sc-221215 | 5 µmol | $390.00 |