Molecular structure of Adenosine 3′,5′-diphosphate disodium salt, CAS Number: 75431-54-8
Adenosine 3′,5′-diphosphate disodium salt (CAS 75431-54-8)
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Alternate Names:
3′-Phosphoadenosine 5′-phosphate; PAP; Adenosine 3′,5′-bisphosphate sodium salt
Application:
Adenosine 3′,5′-diphosphate disodium salt is used to study the kinetics and mechanisms of hydroxysteroid sulfotransferases
CAS Number:
75431-54-8
Purity:
≥96%
Molecular Weight:
471.16
Molecular Formula:
C10H13N5O10P2•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Adenosine 3′,5′-diphosphate disodium salt (PAP) is used to study the kinetics and mechanisms of hydroxysteroid sulfotransferases such as SULT1A1, SULT2A1. It is an inhibitor of hydroxysteroid sulfotransferases. Additionally, it is a key component of the adenosine triphosphate (ATP) cycle and plays an important role in energy metabolism, cell signaling, and gene expression. Adenosine 3′,5′-diphosphate disodium salt is also involved in the synthesis of DNA, RNA, and other nucleic acid components.
Adenosine 3′,5′-diphosphate disodium salt (CAS 75431-54-8) References
- Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms. | Lee, KA., et al. 2003. J Biol Chem. 278: 44593-9. PMID: 12923182
- Identification and purification of sulfotransferases for 20-hydroxysteroid from the larval fat body of a fleshfly, Sarcophaga peregrina. | Matsumoto, E., et al. 2003. Biosci Biotechnol Biochem. 67: 1780-5. PMID: 12951514
- Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A. | Minkler, PE., et al. 2004. Anal Biochem. 328: 203-9. PMID: 15113698
- Novel 3'-phosphoadenosine-5'-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts. | Vaupotic, T., et al. 2007. Fungal Genet Biol. 44: 1109-22. PMID: 17420146
- Isotope exchange at equilibrium indicates a steady state ordered kinetic mechanism for human sulfotransferase. | Tyapochkin, E., et al. 2008. Biochemistry. 47: 11894-9. PMID: 18928301
- para-Nitrophenyl sulfate activation of human sulfotransferase 1A1 is consistent with intercepting the E[middle dot]PAP complex and reformation of E[middle dot]PAPS. | Tyapochkin, E., et al. 2009. J Biol Chem. 284: 29357-64. PMID: 19706609
- Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation. | Tyapochkin, E., et al. 2011. Arch Biochem Biophys. 506: 137-41. PMID: 21111704
- New insights into activation and substrate recognition of polyhydroxyalkanoate synthase from Ralstonia eutropha. | Ushimaru, K., et al. 2013. Appl Microbiol Biotechnol. 97: 1175-82. PMID: 22543354
- Modification of the catalytic function of human hydroxysteroid sulfotransferase hSULT2A1 by formation of disulfide bonds. | Qin, X., et al. 2013. Drug Metab Dispos. 41: 1094-103. PMID: 23444386
- Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin. | Grimm, FA., et al. 2013. Environ Health Perspect. 121: 657-62. PMID: 23584369
- Constriction of a large coronary artery contributes to serotonin-induced myocardial ischemia in the dog with pliable coronary stenosis. | Ichikawa, Y., et al. 1989. J Am Coll Cardiol. 14: 449-59; discussion 460-1. PMID: 2754130
- In vitro percutaneous absorption and metabolism of Bisphenol A (BPA) through fresh human skin. | Toner, F., et al. 2018. Toxicol In Vitro. 47: 147-155. PMID: 29154941
- New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. | Byrne, DP., et al. 2018. Biochem J. 475: 2435-2455. PMID: 29934490
- New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. | Byrne, DP., et al. 2018. Biochem J. 475: 2417-2433. PMID: 29934491
- Chloroplast-to-Nucleus Signaling Regulates MicroRNA Biogenesis in Arabidopsis. | Fang, X., et al. 2019. Dev Cell. 48: 371-382.e4. PMID: 30595534
- Effect of dietary selenium on the metabolism and excretion of 2-acetylaminofluorene in the rat. | Besbris, HJ., et al. 1982. J Toxicol Environ Health. 9: 63-76. PMID: 6801268
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Adenosine 3′,5′-diphosphate disodium salt, 10 mg | sc-210760 | 10 mg | $332.00 | |||
Adenosine 3′,5′-diphosphate disodium salt, 25 mg | sc-210760A | 25 mg | $643.00 | |||
Adenosine 3′,5′-diphosphate disodium salt, 100 mg | sc-210760B | 100 mg | $1984.00 |