Adducin γ Antibody (D-11): sc-365178

Adducin γ Antibody (D-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects Adducin γ in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Adducin γ antibody (D-11) is available in a non-conjugated form, allowing for versatile experimental use. Adducin γ is a crucial member of the adducin family, which consists of cytoskeletal proteins encoded by three distinct genes (α, β, γ). Adducin γ plays a vital role in organizing the cortical actin cytoskeletal network, essential for maintaining cell shape and stability. Adducin γ localizes at the spectrin-actin junction of the plasma membrane, highlighting its importance in linking the cytoskeleton to the plasma membrane, facilitating cellular processes such as signal transduction and cell motility. Notably, Adducin γ shows ubiquitous expression, contrasting with Adducin β, which is predominantly found in brain and hematopoietic tissues. Understanding Adducin γ function and dynamics is critical, as alterations in expression or activity can have significant implications in various physiological and pathological conditions, including those related to cytoskeletal integrity and cellular responses to stress.

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Adducin γ Antibody (D-11) References:

1. Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice.  |  Gilligan, DM., et al. 1999. Proc Natl Acad Sci U S A. 96: 10717-22. PMID: 10485892
2. Linkage but lack of association for blood pressure and the alpha-adducin locus in normotensive twins.  |  Busjahn, A., et al. 1999. J Hypertens. 17: 1437-41. PMID: 10526904
3. Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction.  |  Psaty, BM., et al. 2000. J Hum Hypertens. 14: 95-7. PMID: 10723114
4. Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells.  |  van de Water, B., et al. 2000. J Biol Chem. 275: 25805-13. PMID: 10823823
5. Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.  |  Muro, AF., et al. 2000. Blood. 95: 3978-85. PMID: 10845937
6. beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.  |  Porro, F., et al. 2010. Genes Brain Behav. 9: 84-96. PMID: 19900187
7. γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus.  |  Lou, H., et al. 2013. J Mol Neurosci. 49: 1-10. PMID: 22706708
8. A Mutation in γ-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.  |  Fan, F., et al. 2020. J Am Soc Nephrol. 31: 687-700. PMID: 32029431
9. Hereditary spastic paraparesis presenting as cerebral palsy due to ADD3 variant with mechanistic insight provided by a Drosophila γ-adducin model.  |  Sanchez Marco, SB., et al. 2022. Clin Genet. 102: 494-502. PMID: 36046955
10. Interaction cloning of protein kinase C substrates.  |  Chapline, C., et al. 1993. J Biol Chem. 268: 6858-61. PMID: 8463212
11. Rabphilin-3A: a multifunctional regulator of synaptic vesicle traffic.  |  Burns, ME., et al. 1998. J Gen Physiol. 111: 243-55. PMID: 9450942
12. Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression.  |  Fowler, L., et al. 1998. Cell Growth Differ. 9: 405-13. PMID: 9607561

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Adducin γ Antibody (D-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Adducin γ Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Adducin γ Antibody (D-11) Specifications

Alternate Product Name: Adducin γ

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 631-657

Epitope Target: Adducin γ

Epitope Species: human

Product Reactivity/Detection: Adducin γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Adducin γ Antibody (D-11): P: Blocking Peptide