ADAMTS-17 Antibody (Q-12): sc-100480

ADAMTS-17 Antibody (Q-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects ADAMTS-17 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ADAMTS-17 antibody (Q-12) is available as a non-conjugated format. ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type 1 modules) family comprises zinc-dependent proteases that play crucial roles in various physiological and pathological processes, including tissue remodeling and disease progression such as arthritis and cancer. ADAMTS-17 is a 1,095 amino acid secreted protein expressed in tissues such as liver, prostate, brain, and fetal lung. ADAMTS-17 contains seven N-glycosylation sites essential for stability and function, as these post-translational modifications influence protein folding, localization, and molecular interactions. A conserved cysteine residue in ADAMTS-17′s cysteine-switch motif enables zinc ion binding, critical for regulating enzymatic activity. This balance of structure and modification highlights ADAMTS-17′s role in cellular homeostasis and potential as a therapeutic target.

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ADAMTS-17 Antibody (Q-12) References:

1. ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.  |  Tang, BL. and Hong, W. 1999. FEBS Lett. 445: 223-5. PMID: 10094461
2. Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.  |  Cal, S., et al. 2002. Gene. 283: 49-62. PMID: 11867212
3. Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.  |  Overall, CM., et al. 2004. Biol Chem. 385: 493-504. PMID: 15255181
4. Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage.  |  Davidson, RK., et al. 2006. Arthritis Res Ther. 8: R124. PMID: 16859525
5. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.  |  Kuno, K., et al. 1997. J Biol Chem. 272: 556-62. PMID: 8995297

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADAMTS-17 Antibody (Q-12) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ADAMTS-17 Antibody (Q-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADAMTS-17 Antibody (Q-12) Specifications

Alternate Product Name: ADAMTS17

Product Clone Name: Q-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 543-651

Epitope Target: ADAMTS-17

Epitope Species: human

Product Reactivity/Detection: ADAMTS-17

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ADAMTS-17 Antibody (Q-12): N/A