ADAMDEC1 Antibody (LL-17): sc-100478

ADAMDEC1 Antibody (LL-17) is a mouse monoclonal IgG2a kappa light chain antibody that detects ADAMDEC1 protein of human origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ADAMDEC1 antibody (LL-17) is available as a non-conjugated format. ADAMDEC1, also known as decysin, is a 470 amino acid secreted protein that plays a crucial role in the immune system by modulating dendritic cell activity, which is essential for initiating and regulating immune responses. Found primarily in dendritic cells of the small intestine, spleen, and lymph nodes, ADAMDEC1 is induced during cell maturation in response to T-cell signals, highlighting ADAMDEC1′s importance in adaptive immune response. ADAMDEC1 can bind one zinc ion per subunit, which is vital for structural integrity and function. ADAMDEC1 features a peptidase M12B domain and a prematurely terminated disintegrin domain, but unlike other ADAM family members, lacks an intracellular tail and cysteine-rich domain, which may influence ADAMDEC1′s unique role in immune regulation. Anti-ADAMDEC1 antibody (LL-17) serves as an invaluable tool for researchers studying immune modulation mechanisms and monocyte-to-macrophage differentiation, as ADAMDEC1 expression increases during this process.

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ADAMDEC1 Antibody (LL-17) References:

1. The ADAMDEC1 (decysin) gene structure: evolution by duplication in a metalloprotease gene cluster on chromosome 8p12.  |  Bates, EE., et al. 2002. Immunogenetics. 54: 96-105. PMID: 12037602
2. Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation.  |  Fritsche, J., et al. 2003. Immunology. 110: 450-7. PMID: 14632642
3. Novel candidate genes in unstable areas of human atherosclerotic plaques.  |  Papaspyridonos, M., et al. 2006. Arterioscler Thromb Vasc Biol. 26: 1837-44. PMID: 16741146
4. Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2.  |  Kim, E., et al. 2007. Cytogenet Genome Res. 116: 12-7. PMID: 17268172
5. ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.  |  Jimenez-Pascual, A., et al. 2019. Cancer Discov. 9: 1574-1589. PMID: 31434712
6. ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages.  |  Liu, T., et al. 2020. Biochem Biophys Res Commun. 521: 64-71. PMID: 31627897
7. Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non-small cell lung cancer (NSCLC) via the PI3K/AKT pathway.  |  Zhu, W., et al. 2022. Thorac Cancer. 13: 1027-1039. PMID: 35178875
8. The roles of ADAMDEC1 in trophoblast differentiation during normal pregnancy and preeclampsia.  |  Li, ZH., et al. 2022. Mol Hum Reprod. 28: PMID: 35536241
9. ADAMDEC1 accelerates GBM progression via activation of the MMP2-related pathway.  |  Qi, H., et al. 2022. Front Oncol. 12: 945025. PMID: 36172139
10. ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.  |  Jia, Y., et al. 2023. Exp Cell Res. 429: 113629. PMID: 37187249
11. Knockdown of ADAMDEC1 ameliorates ox-LDL-induced endothelial cell injury and atherosclerosis progression.  |  Wang, X., et al. 2023. Funct Integr Genomics. 24: 1. PMID: 38063920
12. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells.  |  Mueller, CG., et al. 1997. J Exp Med. 186: 655-63. PMID: 9271581

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADAMDEC1 Antibody (LL-17) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ADAMDEC1 Antibody (LL-17) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADAMDEC1 Antibody (LL-17) Specifications

Alternate Product Name: ADAMDEC1

Product Clone Name: LL-17

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 361-471

Epitope Target: ADAMDEC1

Epitope Species: human

Product Reactivity/Detection: ADAMDEC1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ADAMDEC1 Antibody (LL-17): N/A