ADAM22 Antibody (C-2): sc-373931
- ADAM22 Antibody (C-2) is a mouse monoclonal IgG3 κ ADAM22 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 286-319 within an internal region of ADAM22 of human origin
- ADAM22 Antibody (C-2) is recommended for detection of ADAM22 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ADAM22 Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ADAM22 Antibody (C-2). This work is in progress.
ADAM22 Antibody (C-2) is a mouse monoclonal IgG3 antibody that detects ADAM22 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAM22 (C-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ADAM22, a member of the ADAM (a disintegrin and metalloprotease) family, plays a crucial role in mediating cell-cell and cell-matrix interactions, which are essential for processes such as neuronal development and synaptic function. ADAM22 is highly expressed in the brain, where ADAM22 interacts with other proteins, including the neurotrophin receptor TrkB, influencing neurotrophic signaling pathways that are vital for neuronal survival and differentiation. The structural integrity of ADAM22, which includes a disintegrin domain and a metalloprotease domain, is critical for function, as ADAM22 allows for the cleavage of various substrates, thereby modulating signaling pathways that affect cellular communication and plasticity. The genes encoding human ADAM22 and closely related counterpart ADAM23 are located on chromosomes 7q21 and 2q33, respectively, highlighting their evolutionary significance and potential implications in neurological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ADAM22 Antibody (C-2) References:
- Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23. | Sagane, K., et al. 1999. Gene. 236: 79-86. PMID: 10433968
- Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review). | Stone, AL., et al. 1999. J Protein Chem. 18: 447-65. PMID: 10449042
- The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. | Poindexter, K., et al. 1999. Gene. 237: 61-70. PMID: 10524237
- The ADAM gene family: surface proteins with adhesion and protease activity. | Primakoff, P. and Myles, DG. 2000. Trends Genet. 16: 83-7. PMID: 10652535
- ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. | Wolfsberg, TG., et al. 1995. J Cell Biol. 131: 275-8. PMID: 7593158
- Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. | Sagane, K., et al. 1998. Biochem J. 334 (Pt 1): 93-8. PMID: 9693107
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ADAM22 Antibody (C-2) | sc-373931 | 200 µg/ml | $322.00 | |||
ADAM22 Antibody (C-2) AC | sc-373931 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ADAM22 Antibody (C-2) HRP | sc-373931 HRP | 200 µg/ml | $322.00 | |||
ADAM22 Antibody (C-2) FITC | sc-373931 FITC | 200 µg/ml | $336.00 | |||
ADAM22 Antibody (C-2) PE | sc-373931 PE | 200 µg/ml | $349.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 488 | sc-373931 AF488 | 200 µg/ml | $364.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 546 | sc-373931 AF546 | 200 µg/ml | $364.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 594 | sc-373931 AF594 | 200 µg/ml | $364.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 647 | sc-373931 AF647 | 200 µg/ml | $364.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 680 | sc-373931 AF680 | 200 µg/ml | $364.00 | |||
ADAM22 Antibody (C-2) Alexa Fluor® 790 | sc-373931 AF790 | 200 µg/ml | $364.00 | |||
ADAM22 (C-2) Neutralizing Peptide | sc-373931 P | 100 µg/0.5 ml | $69.00 |