ADAM19 Antibody (14J12): sc-73687

ADAM19 Antibody (14J12) is a rat monoclonal IgG2a antibody that detects ADAM19 of mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-ADAM19 antibody (14J12) is available as a non-conjugated format. ADAM19, also known as meltrin b, is a member of the ADAM (a disintegrin and metalloprotease) family, which comprises over 30 membrane-anchored, glycosylated, zinc-dependent proteases that are crucial for various biological processes, including cell-cell interactions and cell-matrix adhesion. ADAM19 is predominantly expressed in the peripheral nervous system during embryonic development, but expression is also found in other tissues such as the placenta, brain, heart, lung, leukocytes, and SW480 cells. ADAM19 plays a significant role in the modulation of neurogenic functions, particularly in the context of the Notch and Delta signaling pathways, which are essential for cell differentiation and development. The structure of ADAM19 includes several functional domains: a signal domain, a pro-domain, a metalloprotease domain, a disintegrin domain that serves as an integrin ligand, a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain, and a cytoplasmic tail. The integrity of these domains is vital for proteolytic activity, particularly the truncation of the cysteine-rich domain, which is necessary for effective cleavage of specific substrates such as α2-macroglobulin. ADAM19 serves as a marker for dendritic cells, highlighting its importance in immune responses.

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ADAM19 Antibody (14J12) References:

1. Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review).  |  Stone, AL., et al. 1999. J Protein Chem. 18: 447-65. PMID: 10449042
2. The ADAM gene family: surface proteins with adhesion and protease activity.  |  Primakoff, P. and Myles, DG. 2000. Trends Genet. 16: 83-7. PMID: 10652535
3. Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation.  |  Fritsche, J., et al. 2000. Blood. 96: 732-9. PMID: 10887142
4. Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta.  |  Wei, P., et al. 2001. Biochem Biophys Res Commun. 280: 744-55. PMID: 11162584
5. Inhibitory antibodies against endopeptidase activity of human adamalysin 19.  |  Zhao, YG., et al. 2001. Biochem Biophys Res Commun. 289: 288-94. PMID: 11708814
6. Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity.  |  Kang, T., et al. 2002. J Biol Chem. 277: 48514-22. PMID: 12393862
7. Meltrin beta mini, a new ADAM19 isoform lacking metalloprotease and disintegrin domains, induces morphological changes in neuronal cells.  |  Kurisaki, T., et al. 2002. FEBS Lett. 532: 419-22. PMID: 12482604
8. ADAM19/adamalysin 19 structure, function, and role as a putative target in tumors and inflammatory diseases.  |  Qi, B., et al. 2009. Curr Pharm Des. 15: 2336-48. PMID: 19601835
9. Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.  |  Xu, S., et al. 2020. Biomark Med. 14: 1573-1584. PMID: 32960074
10. ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and Predicts Prognosis in Osteosarcoma.  |  Wang, J., et al. 2023. Comb Chem High Throughput Screen. 26: 135-148. PMID: 35388751
11. Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model.  |  Li, H., et al. 2024. Lung. 202: 659-672. PMID: 39153120
12. ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.  |  Wolfsberg, TG., et al. 1995. J Cell Biol. 131: 275-8. PMID: 7593158

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADAM19 Antibody (14J12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ADAM19 Antibody (14J12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADAM19 Antibody (14J12) Specifications

Alternate Product Name: ADAM19

Product Clone Name: 14J12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids: 205-705

Epitope Target: ADAM19

Epitope Species: mouse

Product Reactivity/Detection: amino acids 588-705 of ADAM19

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ADAM19 Antibody (14J12): N/A