ADAM12 Antibody (1G3): sc-293225

ADAM12 Antibody (1G3) is a mouse monoclonal IgG3 kappa light chain antibody that detects ADAM12 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ADAM12 antibody (1G3) is available as a non-conjugated format. ADAM12 protein, also known as Meltrin-alpha, plays a crucial role in various biological processes, including fertilization and muscle fusion, by facilitating cell-cell and cell-matrix interactions. ADAM12 monoclonal antibody (1G3) helps study protein involvement in modulating neurogenic function of Notch and Delta, which are essential for proper cell signaling during development. ADAM12 is expressed in multiple tissues, including brain, testis, ovary, and muscle, and exists in two differentially spliced isoforms: a secreted form (ADAM12S) and a membrane-bound form (ADAM12L). These isoforms allow for diverse functional roles in physiological processes, such as egg-sperm fusion, highlighting ADAM12′s significance in reproductive biology. ADAM12 (1G3) antibody serves as an invaluable tool for researchers studying intricate roles of ADAM proteins in health and disease.

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ADAM12 Antibody (1G3) References:

1. Structure-function analysis of the ADAM family of disintegrin-like and metalloproteinase-containing proteins (review).  |  Stone, AL., et al. 1999. J Protein Chem. 18: 447-65. PMID: 10449042
2. The ADAM gene family: surface proteins with adhesion and protease activity.  |  Primakoff, P. and Myles, DG. 2000. Trends Genet. 16: 83-7. PMID: 10652535
3. Cellular roles of ADAM12 in health and disease.  |  Kveiborg, M., et al. 2008. Int J Biochem Cell Biol. 40: 1685-702. PMID: 18342566
4. ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer.  |  Duhachek-Muggy, S. and Zolkiewska, A. 2015. BMC Cancer. 15: 93. PMID: 25886595
5. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.  |  Wang, R., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33952697
6. FOXC2/ADAM12-dependent radiosensitivity of head and neck squamous cell carcinoma cells.  |  Jing, Z., et al. 2022. Head Neck. 44: 212-225. PMID: 34731528
7. ADAM12 is an independent predictor of poor prognosis in liver cancer.  |  Du, S., et al. 2022. Sci Rep. 12: 6634. PMID: 35459884
8. ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.  |  Li, K., et al. 2023. Int Immunopharmacol. 122: 110580. PMID: 37418984
9. Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis.  |  Di Carlo, SE., et al. 2023. Nat Immunol. 24: 1867-1878. PMID: 37798557
10. A metalloprotease-disintegrin participating in myoblast fusion.  |  Yagami-Hiromasa, T., et al. 1995. Nature. 377: 652-6. PMID: 7566181
11. ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.  |  Wolfsberg, TG., et al. 1995. J Cell Biol. 131: 275-8. PMID: 7593158
12. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.  |  Gilpin, BJ., et al. 1998. J Biol Chem. 273: 157-66. PMID: 9417060

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ADAM12 Antibody (1G3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-ADAM12 Antibody (1G3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ADAM12 Antibody (1G3) Specifications

Alternate Product Name: ADAM12

Product Clone Name: 1G3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 208-304

Epitope Target: ADAM12

Epitope Species: human

Product Reactivity/Detection: ADAM12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for ADAM12 Antibody (1G3): N/A