ACTR-IIB Antibody (ACEX12): sc-73682
- ACTR-IIB Antibody (ACEX12) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against the extracellular domain of ACTR-IIB of human origin
- recommended for detection of ACTR-IIB of human origin by WBIP; may cross-react with ACTR-IIA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACTR-IIB Antibody (ACEX12). This work is in progress.
ACTR-IIB Antibody (ACEX12) is a mouse monoclonal IgG1 antibody that detects ACTR-IIB in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). ACTR-IIB, also known as ACVR2B, plays a crucial role in the transforming growth factor beta (TGF-β) signaling pathway, which is essential for regulating various cellular processes, including cell differentiation, proliferation, and apoptosis. ACTR-IIB is primarily located on the cell membrane, where ACTR-IIB interacts with other receptor types to form a signaling complex that transmits extracellular signals into the cell, thereby influencing gene expression and developmental processes. ACTR-IIB′s location in the cell enables precise regulation of signaling pathways vital for maintaining cellular homeostasis and responding to environmental cues. Dysregulation of ACTR-IIB has been implicated in various diseases, including cancer and fibrotic disorders, highlighting ACTR-IIB′s significance as a therapeutic target. Anti-ACTR-IIB antibody (ACEX12) serves as an invaluable tool for researchers studying the complexities of TGF-β signaling and its implications in health and disease.
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ACTR-IIB Antibody (ACEX12) References:
- Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions. | Thompson, TB., et al. 2003. EMBO J. 22: 1555-66. PMID: 12660162
- Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. | Sako, D., et al. 2010. J Biol Chem. 285: 21037-48. PMID: 20385559
- Interference with myostatin/ActRIIB signaling as a therapeutic strategy for Duchenne muscular dystrophy. | Amthor, H. and Hoogaars, WM. 2012. Curr Gene Ther. 12: 245-59. PMID: 22554312
- MiR-195 participates in the placental disorder of preeclampsia via targeting activin receptor type-2B in trophoblastic cells. | Wu, H., et al. 2016. J Hypertens. 34: 1371-9. PMID: 27176145
- Inhibition of the Activin Receptor Type-2B Pathway Restores Regenerative Capacity in Satellite Cell-Depleted Skeletal Muscle. | Formicola, L., et al. 2018. Front Physiol. 9: 515. PMID: 29881353
- Effects of Roux-en-Y gastric bypass on circulating follistatin, activin A, and peripheral ActRIIB signaling in humans with obesity and type 2 diabetes. | Pham, TCP., et al. 2021. Int J Obes (Lond). 45: 316-325. PMID: 32873911
- ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. | Li, J., et al. 2021. J Clin Invest. 131: PMID: 33586684
- The activin receptor ligand trap ActRIIB:ALK4-Fc ameliorates cardiomyopathy induced by neuromuscular disease and diabetes. | Li, J., et al. 2022. FEBS Lett. 596: 3145-3158. PMID: 35920165
- Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. | Queiroz, AL., et al. 2022. Nat Commun. 13: 4633. PMID: 35941104
- Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation. | Bernstein, LR., et al. 2024. Reprod Biol Endocrinol. 22: 52. PMID: 38711160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTR-IIB Antibody (ACEX12) | sc-73682 | 100 µg/ml | $322.00 |