ACTR-IIB Antibody (9D10): sc-134245

ACTR-IIB Antibody (9D10) is a mouse monoclonal IgG2a antibody that detects ACTR-IIB in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ACTR-IIB, also known as ACVR2B, plays a crucial role in the transforming growth factor beta (TGF-β) signaling pathway, which regulates various cellular processes, including cell differentiation, proliferation, and apoptosis. ACTR-IIB is primarily located on the cell membrane, where ACTR-IIB forms a heteromeric complex with type I receptors, facilitating the binding of ligands such as activin. ACTR-IIB′s location enables initiation of intracellular signaling cascades upon ligand binding, which influences gene expression and cellular responses. ACTR-IIB interaction with ligands is vital for proper embryonic development and tissue homeostasis, making ACTR-IIB a significant target for research in developmental biology and disease mechanisms. With high expression levels in the brain, ACTR-IIB is implicated in neurodevelopmental processes, further underscoring ACTR-IIB′s relevance in both health and disease. Anti-ACTR-IIB antibody (9D10) serves as an invaluable tool for researchers exploring the complexities of TGF-β signaling and its implications in various biological contexts.

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ACTR-IIB Antibody (9D10) References:

1. Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis.  |  Oh, SP. and Li, E. 2002. Dev Dyn. 224: 279-90. PMID: 12112458
2. Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats.  |  Bueno, PG., et al. 2011. Mol Cell Endocrinol. 339: 159-64. PMID: 21539891
3. The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques.  |  O'Connell, KE., et al. 2015. FASEB J. 29: 1165-75. PMID: 25466897
4. Activin Decoy Receptor ActRIIB:Fc Lowers FSH and Therapeutically Restores Oocyte Yield, Prevents Oocyte Chromosome Misalignments and Spindle Aberrations, and Increases Fertility in Midlife Female SAMP8 Mice.  |  Bernstein, LR., et al. 2016. Endocrinology. 157: 1234-47. PMID: 26713784
5. Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo.  |  Béchir, N., et al. 2016. Am J Physiol Endocrinol Metab. 310: E539-49. PMID: 26837807
6. Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy.  |  Tinklenberg, J., et al. 2016. Am J Pathol. 186: 1568-81. PMID: 27102768
7. Postnatal Hyperplasic Effects of ActRIIB Blockade in a Severely Dystrophic Muscle.  |  Nielsen, C., et al. 2017. J Cell Physiol. 232: 1774-1793. PMID: 27859236
8. Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology.  |  Sakamoto, K., et al. 2017. Biochem Biophys Rep. 11: 33-39. PMID: 28955765
9. Effects of an ActRIIB.Fc Ligand Trap on Cardiac Function in Simian Immunodeficiency Virus-Infected Male Rhesus Macaques.  |  Guo, W., et al. 2018. J Endocr Soc. 2: 817-831. PMID: 30019021
10. Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta.  |  Tauer, JT. and Rauch, F. 2019. Bone. 128: 115036. PMID: 31419601

The preferred ACTR-IIB antibody is ACTR-IIB Antibody (G-7): sc-376593.