ACTR-IB Antibody (ALEX66): sc-73677
- ACTR-IB Antibody (ALEX66) is a mouse monoclonal IgG1 ACTR-IB antibody, cited in 1 publications, provided at 100 µg/ml
- raised against the extracellular domain of ACTR-IB of human origin
- recommended for detection of ACTR-IB of mouse, rat and human origin by WB and IP; non cross-reactive with ACTR-IIB, ACTR-I, or ACTR-IIA
- also provided azide-free for blocking assays, sc-73677 L, 100 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACTR-IB Antibody (ALEX66). This work is in progress.
ACTR-IB Antibody (ALEX66) is a mouse monoclonal IgG1 antibody that detects ACTR-IB protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ACTR-IB antibody (ALEX66) is available as a non-conjugated format, providing researchers with a reliable tool for studying ACTR-IB protein. ACTR-IB protein, also known as ALK-4, plays a crucial role in the signaling pathways of the transforming growth factor beta superfamily, which are essential for various cellular processes, including cell differentiation and tissue homeostasis. Specifically, ACTR-IB is located on the cell membrane, where ACTR-IB forms a heteromeric complex with type II receptors, facilitating the binding of activin and initiating downstream signaling cascades. This localization is vital as ACTR-IB allows for the precise regulation of gene expression and cellular responses to environmental cues, impacting developmental processes and cellular functions. Understanding the dynamics of ACTR-IB and its interactions is critical for elucidating ACTR-IB′s role in physiological and pathological conditions, making ACTR-IB monoclonal antibody (ALEX66) an invaluable resource for researchers in the field.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ACTR-IB Antibody (ALEX66) References:
- A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development. | Armes, NA., et al. 1999. J Biol Chem. 274: 7929-35. PMID: 10075688
- Cloning and characterization of a human type II receptor for bone morphogenetic proteins. | Rosenzweig, BL., et al. 1995. Proc Natl Acad Sci U S A. 92: 7632-6. PMID: 7644468
- Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. | Cárcamo, J., et al. 1994. Mol Cell Biol. 14: 3810-21. PMID: 8196624
- Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. | Attisano, L., et al. 1993. Cell. 75: 671-80. PMID: 8242742
- The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. | Armes, NA. and Smith, JC. 1997. Development. 124: 3797-804. PMID: 9367435
- Bone morphogenetic proteins and their receptors: potential functions in the brain. | Ebendal, T., et al. 1998. J Neurosci Res. 51: 139-46. PMID: 9469567
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACTR-IB Antibody (ALEX66) | sc-73677 | 100 µg/ml | $322.00 | |||
ACTR-IB Antibody (ALEX66) L | sc-73677 L | 100 µg/0.1 ml | $322.00 |