Date published: 2025-9-17

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Acteoside (CAS 61276-17-3)

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Alternate Names:
Verbascoside; Kusaginin
Application:
Acteoside is an inducer of cell cycle arrest and differentiation in cancer cells
CAS Number:
61276-17-3
Purity:
≥98%
Molecular Weight:
624.59
Molecular Formula:
C29H36O15
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Acteoside, also known as Verbascoside, a natural compound found abundantly in various plants, is recognized as a phenylethanoid glycoside with remarkable properties. Renowned for its anti-inflammatory, anti-bacterial, and anti-oxidant characteristics, Acteoside has captivated scientific interest. Extensive research has explored its potential therapeutic applications, encompassing conditions such as cancer, diabetes, and Alzheimer′s disease. Moreover, Acteoside′s utility in cosmetics and food supplements has also been investigated. Biochemically and physiologically, Acteoside exhibits diverse effects. It displays inhibition of cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-kB), mechanisms that contribute to its anti-inflammatory properties. Furthermore, Acteoside demonstrates the ability to reduce inflammation and safeguard cells against oxidative damage. Its broad spectrum of activities encompasses anti-inflammatory, anti-bacterial, and anti-oxidant actions. Notably, it has exhibited inhibitory effects on the growth of specific cancer cell lines, further underlining its potential therapeutic significance. The precise mechanism of Acteoside′s action remains a subject of ongoing investigation. Studies have unveiled its ability to impede the activity of specific enzymes, including cyclooxygenase-2 (COX-2), responsible for generating inflammatory mediators. Additionally, Acteoside can inhibit the activity of certain proteins like nuclear factor kappa B (NF-kB), which modulates the transcription of pro-inflammatory genes. As research on Acteoside continues to advance, a deeper understanding of its properties and mechanisms will emerge. This knowledge will contribute to harnessing its potential for therapeutic interventions and fostering advancements in various scientific fields, propelling the development of novel treatments and applications.


Acteoside (CAS 61276-17-3) References

  1. Advanced research on acteoside for chemistry and bioactivities.  |  He, J., et al. 2011. J Asian Nat Prod Res. 13: 449-64. PMID: 21534045
  2. Current advances in acteoside biosynthesis pathway elucidation and biosynthesis.  |  Zhou, Y., et al. 2020. Fitoterapia. 142: 104495. PMID: 32045692
  3. Inhibitory activity of acteoside in melanoma via regulation of the ERβ-Ras/Raf1-STAT3 pathway.  |  Wu, Y., et al. 2021. Arch Biochem Biophys. 710: 108978. PMID: 34174222
  4. Anticancer effects of acteoside: Mechanistic insights and therapeutic status.  |  Khan, RA., et al. 2022. Eur J Pharmacol. 916: 174699. PMID: 34919888
  5. Acteoside, the Main Bioactive Compound in Osmanthus fragrans Flowers, Palliates Experimental Colitis in Mice by Regulating the Gut Microbiota.  |  Liu, Y., et al. 2022. J Agric Food Chem. 70: 1148-1162. PMID: 35073073
  6. Acteoside exerts immunomodulatory effects on dendritic cells via aryl hydrocarbon receptor activation and ameliorates Th2-mediated allergic asthma by inducing Foxp3+ regulatory T cells.  |  Chang, JH., et al. 2022. Int Immunopharmacol. 106: 108603. PMID: 35123286
  7. Acteoside attenuates hydrogen peroxide-induced injury of retinal ganglion cells via the CASC2/miR-155/mTOR axis.  |  Xi, X., et al. 2022. Ann Transl Med. 10: 5. PMID: 35242850
  8. Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity.  |  Wu, M., et al. 2022. J Leukoc Biol. 112: 875-885. PMID: 35638582
  9. A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue.  |  Zhang, S., et al. 2022. Biomed Pharmacother. 150: 113004. PMID: 35658245
  10. Acteoside attenuates RSV-induced lung injury by suppressing necroptosis and regulating metabolism.  |  Ling, X., et al. 2022. Front Pharmacol. 13: 870928. PMID: 36059973
  11. Acteoside (Verbascoside): A prospective therapeutic alternative against Hepatocellular Carcinoma by inhibiting the expression of AXL, FGFR, BRAF, TIE2 and RAF1 targets.  |  Kityania, S., et al. 2022. Comb Chem High Throughput Screen.. PMID: 36321230
  12. Acteoside attenuates acute lung injury following administration of cobra venom factor to mice.  |  Guo, J., et al. 2022. Heliyon. 8: e11622. PMID: 36411899
  13. Acteoside palliates d-galactose induced cognitive impairment by regulating intestinal homeostasis.  |  Li, M., et al. 2023. Food Chem. 421: 135978. PMID: 37094395

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acteoside, 20 mg

sc-281509
20 mg
$617.00