ACP1α/β Antibody (Q18): sc-100343
- ACP1α/β Antibody (Q18) is a mouse monoclonal IgG2b κ ACP1α/β antibody, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant ACP1α/β of human origin
- recommended for detection of ACP1α and ACP1β of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACP1α/β Antibody (Q18). This work is in progress.
ACP1α/β Antibody (Q18) is a mouse monoclonal IgG2b kappa light chain antibody that detects ACP1 alpha/beta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ACP1 alpha/beta antibody (Q18) is available as a non-conjugated format. ACP1 protein plays a crucial role in regulating intracellular concentrations of flavoenzymes and flavin coenzymes, which is essential for maintaining cellular homeostasis. Specifically, red cell acid phosphatase, known as ACP1, catalyzes the transfer of phosphate from phosphate ester substrates to suitable acceptor alcohols, such as methanol and glycerol, thereby influencing various metabolic pathways. Human ACP1 gene, located on chromosome 2p25, encodes two isozymes, Bf (alpha) and Bs (beta), which are both 157 amino acids in length but differ in sequence over a 34-residue segment, suggesting variations in substrate specificity. Both isoforms are not glycosylated, which may impact functional properties and interactions within the cell. Understanding the distinct roles of these isozymes is vital for elucidating contributions to metabolic regulation and potential implications in disease states.
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ACP1α/β Antibody (Q18) References:
- ACP1 and Th class of immunological disease: evidence of interaction with gender. | Gloria-Bottini, F., et al. 2007. Int Arch Allergy Immunol. 143: 170-6. PMID: 17284925
- ACP1 genetic polymorphism and colon cancer. | Spina, C., et al. 2008. Cancer Genet Cytogenet. 186: 61-2. PMID: 18786445
- ACP1 genotype, glutathione reductase activity, and riboflavin uptake affect cardiovascular risk in the obese. | Apelt, N., et al. 2009. Metabolism. 58: 1415-23. PMID: 19570551
- Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study. | Teruel, M., et al. 2012. Tissue Antigens. 80: 61-4. PMID: 22428720
- The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis. | Alho, I., et al. 2013. Tumour Biol. 34: 1979-89. PMID: 23584899
- Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance. | Qiu, X., et al. 2016. Dig Dis Sci. 61: 149-57. PMID: 26386860
- ACP1 Genetic Polymorphism and Coronary Artery Disease: Evidence of Effects on Clinical Parameters of Cardiac Function. | Gloria-Bottini, F., et al. 2013. Cardiol Res. 4: 101-108. PMID: 28352429
- Discovery and biological evaluation of novel dual PTP1B and ACP1 inhibitors for the treatment of insulin resistance. | Feng, B., et al. 2024. Bioorg Med Chem. 97: 117545. PMID: 38070352
- Targeting prostate tumor low-molecular weight tyrosine phosphatase for oxidation-sensitizing therapy. | Stanford, SM., et al. 2024. Sci Adv. 10: eadg7887. PMID: 38295166
- ACP1 and human adaptability. 1. Association with common diseases: a case-control study. | Bottini, E., et al. 1995. Hum Genet. 96: 629-37. PMID: 8522318
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACP1α/β Antibody (Q18) | sc-100343 | 100 µg/ml | $339.00 |