ACOT9 Antibody (G-6): sc-514330

ACOT9 Antibody (G-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects ACOT9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ACOT9 antibody (G-6) is available as the non-conjugated form. ACOT9, also known as acyl-CoA thioesterase 9, ACATE2, or mitochondrial acyl-CoA thioesterase of 48 kDa, plays a crucial role in lipid metabolism by catalyzing the hydrolysis of acyl-CoA to produce coenzyme A and free fatty acids. This enzymatic activity is vital for maintaining cellular lipid homeostasis, as ACOT9 regulates the levels of fatty acids and acyl-CoAs, which are essential for various metabolic processes. ACOT9 consists of 406 amino acids and features a conserved C-terminal domain that is believed to be important for its catalytic function. Located on chromosome X, ACOT9 is expressed predominantly in the mitochondrion, highlighting its significance in mitochondrial fatty acid metabolism. ACOT9′s ability to modulate fatty acid levels makes ACOT9 a key player in energy production and storage, as well as in the regulation of signaling pathways associated with metabolic diseases.

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ACOT9 Antibody (G-6) References:

1. Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase.  |  Poupon, V., et al. 1999. J Biol Chem. 274: 19188-94. PMID: 10383425
2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.  |  Lai, CH., et al. 2000. Genome Res. 10: 703-13. PMID: 10810093
3. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.  |  Hunt, MC., et al. 2005. J Lipid Res. 46: 2029-32. PMID: 16103133
4. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.  |  Hunt, MC., et al. 2006. FASEB J. 20: 1855-64. PMID: 16940157
5. Solubilization, purification and kinetic properties of three membrane-bound long-chain acyl-coenzyme-A thioesterases from microsomes of photosynthetic tissue.  |  Murphy, DJ., et al. 1984. Eur J Biochem. 142: 43-8. PMID: 6146527
6. Characterization of acyl-CoA thioesterase activity in isolated rat liver peroxisomes. Partial purification and characterization of a long-chain acyl-CoA thioesterase.  |  Wilcke, M. and Alexson, SE. 1994. Eur J Biochem. 222: 803-11. PMID: 7913034
7. Isolation and characterization of microsomal acyl-CoA thioesterase. A member of the rat liver microsomal carboxylesterase multi-gene family.  |  Alexson, SE., et al. 1993. Eur J Biochem. 214: 719-27. PMID: 8100522

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACOT9 Antibody (G-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ACOT9 Antibody (G-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACOT9 Antibody (G-6) Specifications

Alternate Product Name: ACOT9

Product Clone Name: G-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 11-29

Epitope Target: ACOT9

Epitope Species: human

Product Reactivity/Detection: ACOT9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ACOT9 Antibody (G-6): P: Blocking Peptide