Molecular structure of Aconitine, CAS Number: 302-27-2
Aconitine (CAS 302-27-2)
Alternate Names:
Aconitine is also known as Acetylbenzoylaconine.
Application:
Aconitine is a lipid-soluble and potent neurotoxin that activates voltage gated, tetrodotoxin-sensitive sodium channels.
CAS Number:
302-27-2
Purity:
≥98%
Molecular Weight:
645.73
Molecular Formula:
C34H47NO11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Aconitine is a lipid-soluble and potent neurotoxin that activates voltage gated sodium channels. Aconitine can inhibit non-quantal acetylcholine release and can induce neuromuscular blockage, specifically blocking the nerve compound action potential. Studies show that Aconitine is toxic to neuron cells at a concentration of 2%. Aconitine can block tetrodotoxin-sensitive Na+ channels. Aconitine is also known as Acetylbenzoylaconine, and (1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate.
Aconitine (CAS 302-27-2) References
- Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells. | Peng, C., et al. 2009. Arch Pharm Res. 32: 1533-43. PMID: 20091266
- Pharmacokinetics of aconitine as the targeted marker of Fuzi (Aconitum carmichaeli) following single and multiple oral administrations of Fuzi extracts in rat by UPLC/MS/MS. | Tang, L., et al. 2012. J Ethnopharmacol. 141: 736-41. PMID: 21924342
- Pharmacokinetics of aconitine in rat skin after oral and transdermal gel administrations. | Zhang, QL., et al. 2012. Biomed Chromatogr. 26: 622-6. PMID: 22139640
- Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine. | Yu, SP. and Van der Kloot, W. 1990. Neurosci Lett. 117: 111-6. PMID: 2290606
- Cladosporium cladosporioides XJ-AC03, an aconitine-producing endophytic fungus isolated from Aconitum leucostomum. | Yang, K., et al. 2013. World J Microbiol Biotechnol. 29: 933-8. PMID: 23269506
- Observation on effects of aconitine via acupoint injection in rabbits. | Ni, F., et al. 2013. Chin J Integr Med. 19: 36-41. PMID: 23275014
- Blocking effects of hypaconitine and aconitine on nerve action potentials in phrenic nerve-diaphragm muscles of mice. | Muroi, M., et al. 1990. Neuropharmacology. 29: 567-72. PMID: 2385329
- Gram-scale purification of aconitine and identification of lappaconitine in Aconitum karacolicum. | Tarbe, M., et al. 2017. Fitoterapia. 120: 85-92. PMID: 28552596
- Quantitative analysis of aconitine in body fluids in a case of aconitine poisoning. | Cho, YS., et al. 2020. Forensic Sci Med Pathol. 16: 330-334. PMID: 31802365
- Pharmacokinetic effects of ginsenoside Rg1 on aconitine, benzoylaconine and aconine by UHPLC-MS/MS. | Xu, Y., et al. 2020. Biomed Chromatogr. 34: e4793. PMID: 31919877
- Clinical relationship between blood concentration and clinical symptoms in aconitine intoxication. | Jeon, SY., et al. 2021. Am J Emerg Med. 40: 184-187. PMID: 33243534
- An Effective Phytoconstituent Aconitine: A Realistic Approach for the Treatment of Trigeminal Neuralgia. | Çankal, D., et al. 2021. Mediators Inflamm. 2021: 6676063. PMID: 33935591
- Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro. | Li, Q., et al. 2023. J Ethnopharmacol. 303: 116029. PMID: 36503029
Inhibitor of:
Na+ CP type IIIβ, Olfr787, Olfr853, Olfr854, Olfr987, Olfr988, sodium channel type I, sodium channel type II, sodium channel type III, and sodium channel type IV.Activator of:
Na+ CP type IIα, Na+ CP type IVα, Na+ CP type IXα, Na+ CP type Vα, Na+ CP type Xα, NaS-1, SCNM1, sodium channel type I, sodium channel type II, sodium channel type III, and sodium channel type IV.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aconitine, 25 mg | sc-202441 | 25 mg | $300.00 | |||
Aconitine, 50 mg | sc-202441A | 50 mg | $450.00 | |||
Aconitine, 100 mg | sc-202441B | 100 mg | $650.00 | |||
Aconitine, 250 mg | sc-202441C | 250 mg | $1252.00 | |||
Aconitine, 500 mg | sc-202441D | 500 mg | $2050.00 |