Acinus Antibody (2005C3a): sc-81177

Acinus Antibody (2005C3a) is a mouse monoclonal IgG1 antibody that detects Acinus protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Acinus antibody (2005C3a) is available as a non-conjugated monoclonal isotype antibody. Acinus protein plays a crucial role in apoptosis, specifically in chromatin condensation, which is essential for the orderly dismantling of cellular components during programmed cell death. Acinus protein is predominantly localized in the nucleus, where Acinus interacts with both the nuclear membrane and nucleoplasm, facilitating function in apoptosis. Notably, Acinus protein undergoes post-translational modifications, including cleavage by caspase-3, which generates soluble protein p23. This cleavage is vital for inducing chromatin condensation, underscoring Acinus protein′s importance in the apoptotic pathway. Acinus exists in various isoforms, such as AcinusL, AcinusS, and AcinusS′, which arise from alternative splicing and may have distinct functional roles in cellular processes. Acinus protein′s ability to mediate chromatin condensation highlights significance in maintaining cellular integrity and regulating apoptosis, making Acinus (2005C3a) antibody an essential tool for researchers studying these critical biological processes.

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Acinus Antibody (2005C3a) References:

1. Emerging roles of caspase-3 in apoptosis.  |  Porter, AG. and Jänicke, RU. 1999. Cell Death Differ. 6: 99-104. PMID: 10200555
2. Apoptotic nuclear morphological change without DNA fragmentation.  |  Sakahira, H., et al. 1999. Curr Biol. 9: 543-6. PMID: 10339431
3. Apoptosis: cell death defined by caspase activation.  |  Samali, A., et al. 1999. Cell Death Differ. 6: 495-6. PMID: 10381647
4. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation.  |  Sahara, S., et al. 1999. Nature. 401: 168-73. PMID: 10490026
5. ASAP, a novel protein complex involved in RNA processing and apoptosis.  |  Schwerk, C., et al. 2003. Mol Cell Biol. 23: 2981-90. PMID: 12665594
6. Chromatin condensation during apoptosis requires ATP.  |  Kass, GE., et al. 1996. Biochem J. 318 (Pt 3): 749-52. PMID: 8836114
7. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.  |  Ishikawa, K., et al. 1998. DNA Res. 5: 169-76. PMID: 9734811

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Acinus Antibody (2005C3a) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Acinus Antibody (2005C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Acinus Antibody (2005C3a) Specifications

Alternate Product Name: Acinus

Product Clone Name: 2005C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Acinus

Epitope Species: human

Product Reactivity/Detection: Acinus

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Acinus Antibody (2005C3a): N/A