Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (236): sc-65843
- Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (236) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against α1 synthetic peptide 152-167 of Torpedo origin
- recommended for detection of nicotinic AChRα1 of Torpedo origin by WB and IF
- See Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 (153): sc-65829 for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (236). This work is in progress.
AChRα1 Antibody (236) is a rat monoclonal IgG2a antibody that detects AChRα1 in Torpedo species through applications such as western blotting (WB) and immunofluorescence (IF). AChRα1, also known by various aliases including ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, or CHRNA1, is a crucial component of the nicotinic acetylcholine receptor family, which plays a vital role in neurotransmission. This 482 amino acid multi-pass membrane protein is integral to the function of the neuromuscular junction, where AChRα1 facilitates the binding of acetylcholine, leading to the opening of an ion channel that allows the influx of sodium ions, ultimately triggering muscle contraction. AChRα1′s importance extends beyond muscle activation; AChRα1 is also involved in synaptic plasticity and cognitive functions in the central nervous system. Notably, AChRα1 exists in two alternatively spliced isoforms, with isoform 1 being exclusively expressed in skeletal muscle, while isoform 2 is widely distributed across various tissues, including the brain, heart, kidney, liver, lung, and thymus. This broad expression pattern underscores AChRα1′s significance in both peripheral and central nervous system functions, making AChRα1 a critical target for research in neuromuscular disorders and neurodegenerative diseases. Anti-AChRα1 antibody (236) is an essential tool for researchers aiming to explore the intricate mechanisms of neurotransmission and receptor function in Torpedo species.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (236) | sc-65843 | 200 µg/ml | $322.00 |