ACHN Whole Cell Lysate: sc-364365

The ACHN Whole Cell Lysate is sourced from a human renal adenocarcinoma cell line, which is extensively employed in the study of kidney cell biology and carcinogenesis. Originating from a metastatic site in the pleural effusion of a 22-year-old male, ACHN cells have been instrumental since their establishment in the 1970s. This lysate provides a rich source of cellular material, including proteins, nucleic acids, and other biomolecules, reflecting the state of cells under cultured conditions. In research, the ACHN lysate is pivotal for understanding the molecular dynamics within renal cells, particularly how they respond to various cellular stresses and environmental factors. Scientists utilize this lysate to investigate gene expression profiles, signaling pathways, and metabolic activities specific to renal cancer cells. This has implications for uncovering the underlying mechanisms of cell proliferation and survival. Moreover, in the realm of proteomics and genomics, the ACHN lysate serves as a comparative tool against healthy kidney cell lysates, aiding in the identification of cancer-specific markers and the exploration of molecular distinctions. Its application in biochemical assays and molecular biology techniques such as Western blotting, mass spectrometry, and chromatography further enhances its value, making it a cornerstone in non-clinical research focused on kidney cellular processes and pathology.

ACHN Whole Cell Lysate References:

1. VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2α.  |  Yang, J., et al. 2022. Cell Biosci. 12: 203. PMID: 36536448