Molecular structure of Acetylethylcholine mustard hydrochloride, CAS Number: 103994-00-9
Acetylethylcholine mustard hydrochloride (CAS 103994-00-9)
Alternate Names:
2-[2-chloroethyl(ethyl)amino]ethyl acetate hydrochloride; Acetyl AF-64
Application:
Acetylethylcholine mustard hydrochloride is an inhibitor of choactase (choline acetyl-transferase)
CAS Number:
103994-00-9
Purity:
≥97%
Molecular Weight:
230.13
Molecular Formula:
C8H16CINO2•HCI
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetylethylcholine mustard hydrochloride is an inhibitor of choactase (choline acetyl-transferase). Acetylethylcholine mustard hydrochloride is also a precursor for ethylcholine mustard aziridinium ion (AF-64A). This compound is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a specific presynaptic long action cholinotoxin.
Acetylethylcholine mustard hydrochloride (CAS 103994-00-9) References
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- Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model. | Uabundit, N., et al. 2010. J Ethnopharmacol. 127: 26-31. PMID: 19808086
- Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease. | Chonpathompikunlert, P., et al. 2010. Food Chem Toxicol. 48: 798-802. PMID: 20034530
- Purple rice berry is neuroprotective and enhances cognition in a rat model of Alzheimer's disease. | Pannangrong, W., et al. 2011. J Med Food. 14: 688-94. PMID: 21510741
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- Laser acupuncture improves memory impairment in an animal model of Alzheimer's disease. | Sutalangka, C., et al. 2013. J Acupunct Meridian Stud. 6: 247-51. PMID: 24139462
- Moringa oleifera mitigates memory impairment and neurodegeneration in animal model of age-related dementia. | Sutalangka, C., et al. 2013. Oxid Med Cell Longev. 2013: 695936. PMID: 24454988
- Mangifera indica fruit extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment. | Wattanathorn, J., et al. 2014. Oxid Med Cell Longev. 2014: 132097. PMID: 24672632
- AF64 depletes hypothalamic high-affinity choline uptake and disrupts the circadian rhythm of locomotor activity without altering the density of nicotinic acetylcholine receptors. | Morley, BJ. and Murrin, LC. 1989. Brain Res. 504: 238-46. PMID: 2598026
- Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. | Charoensook, SN., et al. 2017. Integr Biol (Camb). 9: 956-967. PMID: 29168874
- The antihypertensive effect of ethylcholine aziridinium (AF64A), a cholinergic neurotoxin, in spontaneously hypertensive rats, following administration into the posterior hypothalamus. | Eliash, S., et al. 1988. Life Sci. 42: 1669-74. PMID: 3367686
- Method for the quantitation and characterization of the cholinergic neurotoxin, monoethylcholine mustard aziridinium ion (AF64A). | Sandberg, K., et al. 1985. J Neurosci Methods. 14: 143-8. PMID: 3839874
- Facilitation of 2-deoxyglucose uptake in rat cortex and hippocampus slices by somatostatin is independent of cholinergic activity. | Shibata, S., et al. 1993. Eur J Pharmacol. 231: 381-8. PMID: 8095464
- Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. | Cheng, DH. and Tang, XC. 1998. Pharmacol Biochem Behav. 60: 377-86. PMID: 9632220
Inhibitor of:
Choactase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetylethylcholine mustard hydrochloride, 5 mg | sc-281685 | 5 mg | $50.00 | |||
Acetylethylcholine mustard hydrochloride, 25 mg | sc-281685A | 25 mg | $174.00 |