Date published: 2025-10-14

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Acetylacetone (CAS 123-54-6)

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Alternate Names:
2,4-Pentanedione
Application:
Acetylacetone is an indicator for the complexometric titration of Fe(III)
CAS Number:
123-54-6
Molecular Weight:
100.12
Molecular Formula:
C5H8O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Acetylacetone, also referred to as 2,4-pentanedione or AcAc, is a versatile organic compound (C5H8O2) that finds application in various fields such as chemistry and biology. Its physical properties include being a colorless liquid with a pleasant odor, and it can dissolve in water, ethanol, and ether. Acetylacetone serves multiple purposes, acting as a reagent for synthesizing organic compounds, a catalyst in organic reactions, and a biochemical probe for investigating enzyme structure and function. In scientific research, it has been extensively utilized due to its broad range of applications. Additionally, it serves as a substrate for enzyme assays and a model compound for studying enzyme-catalyzed reactions in laboratory applications.


Acetylacetone (CAS 123-54-6) References

  1. Acetylacetone-cleaving enzyme Dke1: a novel C-C-bond-cleaving enzyme from Acinetobacter johnsonii.  |  Straganz, GD., et al. 2003. Biochem J. 369: 573-81. PMID: 12379146
  2. (Acetyl-acetonato-κO,O')bis-[2-(5-methyl-3-phenyl-pyrazin-2-yl-κN)phen-yl-κC]iridium(III).  |  Ge, GP., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: m306. PMID: 22412448
  3. Polypyridyl-functionalizated alkynyl gold(i) metallaligands supported by tri- and tetradentate phosphanes.  |  Ferrer, M., et al. 2017. Dalton Trans. 46: 13920-13934. PMID: 28972220
  4. Polyethyleneimine-Coated Manganese Oxide Nanoparticles for Targeted Tumor PET/MR Imaging.  |  Zhu, J., et al. 2018. ACS Appl Mater Interfaces. 10: 34954-34964. PMID: 30234287
  5. Solution-Processed Warm White Organic Light-Emitting Diodes Based on a Blue Thermally Activated Delayed Fluorescence Dendrimer.  |  Liao, X., et al. 2018. Chempluschem. 83: 274-278. PMID: 31957278
  6. [Pt(O,O'-acac)(γ-acac)(DMS)]: Alternative Strategies to Overcome Cisplatin-Induced Side Effects and Resistance in T98G Glioma Cells.  |  Astesana, V., et al. 2021. Cell Mol Neurobiol. 41: 563-587. PMID: 32430779
  7. Biosynthesis of acetylacetone inspired by its biodegradation.  |  Zhou, Y., et al. 2020. Biotechnol Biofuels. 13: 88. PMID: 32454892
  8. Use of acetylacetone for nano-level assay of fluvoxamine maleate in pure form and pharmaceutical formulation.  |  Abu-Hassan, AA., et al. 2020. Luminescence. 35: 1360-1365. PMID: 32519373
  9. A novel isosteviol-based bifunctional squaramide organocatalyst for enantioselective Michael addition of acetylacetone to nitroolefins.  |  Ma, Z., et al. 2022. Chirality. 34: 77-85. PMID: 34747045
  10. Bis[3-(anthracen-9-yl)pentane-2,4-dionato-κ2 O,O'](N,N-di-methyl-formamide-κO)[tris-(pyrazol-1-yl-κN 2)hydroborato]europium(III).  |  Mikhalyova, EA., et al. 2022. Acta Crystallogr E Crystallogr Commun. 78: 103-107. PMID: 35145732
  11. Doxorubicin delivery systems with an acetylacetone-based block in cholesterol-terminated copolymers: Diverse activity against estrogen-dependent and estrogen-independent breast cancer cells.  |  Misiak, P., et al. 2022. Chem Phys Lipids. 245: 105194. PMID: 35288126
  12. Acetylacetone Interferes with Carbon and Nitrogen Metabolism of Microcystis aeruginosa by Cutting Off the Electron Flow to Ferredoxin.  |  Yilimulati, M., et al. 2022. Environ Sci Technol. 56: 9683-9692. PMID: 35696645
  13. [Determination of acetylacetone in workplace air by solvent desorption-gas chromatography].  |  Chen, GL., et al. 2022. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 40: 861-864. PMID: 36510724

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acetylacetone, 100 ml

sc-239193
100 ml
$38.00

Acetylacetone, 500 ml

sc-239193A
500 ml
$63.00