Molecular structure of Acetyl Isoniazid, CAS Number: 1078-38-2
Acetyl Isoniazid (CAS 1078-38-2)
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Alternate Names:
2-Acetylhydrazide-4-pyridinecarboxylic Acid
Application:
Acetyl Isoniazid is a metabolite of isoniazid in plasma
CAS Number:
1078-38-2
Molecular Weight:
179.18
Molecular Formula:
C8H9N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetyl isoniazid is a metabolite of isoniazid. The activation and metabolism of isoniazid illustrate important concepts in metabolism and kinetics. Isoniazid is activated by mycobacterial catalase-peroxidase enzyme (KatG) within Mycobacterium tuberculosis. The activated form of isoniazid then inhibits the synthesis of mycolic acids, essential components of the bacterial cell wall. isoniazid is primarily metabolized through acetylation by N-acetyltransferase 2 (NAT2) to form acetyl isoniazid.
Acetyl Isoniazid (CAS 1078-38-2) References
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- Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis. | HUGHES, HB., et al. 1954. Am Rev Tuberc. 70: 266-73. PMID: 13180863
- The quantitative determination of isoniazid and para-aminosalicylic acid in body fluids. | MAHER, JR., et al. 1957. Am Rev Tuberc. 76: 852-61. PMID: 13478839
- Kinetic characteristics of the acetylation of isoniazid and p-aminosalicylic acid by a liver-enzyme preparation. | JENNE, JW. and BOYER, PD. 1962. Biochim Biophys Acta. 65: 121-7. PMID: 13957595
- Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment. | Eisenhut, M., et al. 2012. Tuberc Res Treat. 2012: 327027. PMID: 23091716
- Role of CYP3A in isoniazid metabolism in vivo. | Liu, K., et al. 2014. Drug Metab Pharmacokinet. 29: 219-22. PMID: 24172716
- Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid. | Chirehwa, MT., et al. 2019. J Antimicrob Chemother. 74: 139-148. PMID: 30239829
- Model-Based Assessment of Variability in Isoniazid Pharmacokinetics and Metabolism in Patients Co-Infected With Tuberculosis and HIV: Implications for a Novel Dosing Strategy. | Sundell, J., et al. 2020. Clin Pharmacol Ther. 108: 73-80. PMID: 32017035
- Quantification of pyrazinamide, isoniazid, acetyl-isoniazid, and rifampicin by a high-performance liquid chromatography method in human plasma from patients with tuberculosis. | Hernández-González, O., et al. 2021. J Sep Sci. 44: 521-529. PMID: 33200497
- Alternative Methods for Therapeutic Drug Monitoring and Dose Adjustment of Tuberculosis Treatment in Clinical Settings: A Systematic Review. | Rao, PS., et al. 2023. Clin Pharmacokinet. 62: 375-398. PMID: 36869170
- Isoniazid inactivation in Finns and Lapps as demonstrated by various methods. | Tittinen, H., et al. 1973. Am Rev Respir Dis. 108: 375-8. PMID: 4720700
- Spectrophotofluorometric assay for isoniazid and acetyl isoniazid in plasma adapted to pediatric studies. | Olson, WA., et al. 1977. Clin Chem. 23: 745-8. PMID: 844172
- Monoacetylhydrazine as a metabolite of isoniazid in man. | Timbrell, JA., et al. 1977. Clin Pharmacol Ther. 22: 602-8. PMID: 913027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl Isoniazid, 50 mg | sc-391344A | 50 mg | $275.00 | |||
Acetyl Isoniazid, 100 mg | sc-391344 | 100 mg | $367.00 | |||
Acetyl Isoniazid, 250 mg | sc-391344B | 250 mg | $755.00 | |||
Acetyl Isoniazid, 500 mg | sc-391344C | 500 mg | $1484.00 | |||
Acetyl Isoniazid, 1 g | sc-391344D | 1 g | $2336.00 |