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Acetyl coenzyme A trilithium salt (CAS 32140-51-5)

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Alternate Names:
Acetyl coenzyme A trilithium salt also known as Acetyl-S-CoA Li3; salt
Application:
Acetyl coenzyme A trilithium salt is a cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions
CAS Number:
32140-51-5
Molecular Weight:
881
Molecular Formula:
C23H35N7O17P3S•3Li
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Acetyl coenzyme A trilithium salt is a lithium salt of an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl coenzyme A trilithium salt is a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-coA is a positive regulator of pyruvate carboxylase and is a precursor of the neurotransmitter acetylcholine.


Acetyl coenzyme A trilithium salt (CAS 32140-51-5) References

  1. Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells.  |  Kalisch, BE., et al. 2002. J Neurochem. 81: 624-35. PMID: 12065671
  2. Enzymes of Poly-(beta)-Hydroxybutyrate Metabolism in Soybean and Chickpea Bacteroids.  |  Kim, SA. and Copeland, L. 1996. Appl Environ Microbiol. 62: 4186-90. PMID: 16535445
  3. Formaldehyde-induced histone modifications in vitro.  |  Lu, K., et al. 2008. Chem Res Toxicol. 21: 1586-93. PMID: 18656964
  4. Enzyme:nanoparticle bioconjugates with two sequential enzymes: stoichiometry and activity of malate dehydrogenase and citrate synthase on Au nanoparticles.  |  Keighron, JD. and Keating, CD. 2010. Langmuir. 26: 18992-9000. PMID: 21114258
  5. Methods for analysis of acetyl-CoA synthase applications to bacterial and archaeal systems.  |  Grahame, DA. 2011. Methods Enzymol. 494: 189-217. PMID: 21402216
  6. LC-MS/MS-based analysis of coenzyme A and short-chain acyl-coenzyme A thioesters.  |  Neubauer, S., et al. 2015. Anal Bioanal Chem. 407: 6681-8. PMID: 26168961
  7. Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase.  |  Elkalaf, M., et al. 2016. PLoS One. 11: e0161413. PMID: 27537184
  8. Kinetics of Intracellular Electron Generation in Shewanella oneidensis MR-1.  |  Ishiki, K. and Shiigi, H. 2019. Anal Chem. 91: 14401-14406. PMID: 31631651
  9. In Vitro N-Terminal Acetylation of Bacterially Expressed Parvalbumins by N-Terminal Acetyltransferases from Escherichia coli.  |  Lapteva, YS., et al. 2021. Appl Biochem Biotechnol. 193: 1365-1378. PMID: 32394317
  10. Hepatic N-acetyltransferases: selective inactivation in vivo by a carcinogenic N-arylhydroxamic acid.  |  Smith, TJ. and Hanna, PE. 1988. Biochem Pharmacol. 37: 427-34. PMID: 3257389
  11. Changes in malate dehydrogenase isoenzymes during differentiation of rabbit bone marrow erythroid cells.  |  Setchenska, MS. and Arnstein, HR. 1979. Int J Biochem. 10: 817-21. PMID: 510663
  12. Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.  |  Mayer, JH. and Tomlinson, DR. 1983. Diabetologia. 25: 433-8. PMID: 6197336
  13. Comparative developmental toxicity and metabolism of nitrazepam in rats and mice.  |  Takeno, S., et al. 1993. Toxicol Appl Pharmacol. 121: 233-8. PMID: 8346540
  14. Key role of acetyl-CoA in cytoplasm of nerve terminals in disturbances of acetylcholine metabolism in brain.  |  Szutowicz, A., et al. 1997. Folia Neuropathol. 35: 241-3. PMID: 9833402

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Acetyl coenzyme A trilithium salt, 1 mg

sc-214465
1 mg
$69.00

Acetyl coenzyme A trilithium salt, 5 mg

sc-214465A
5 mg
$119.00

Acetyl coenzyme A trilithium salt, 25 mg

sc-214465B
25 mg
$389.00

Acetyl coenzyme A trilithium salt, 100 mg

sc-214465C
100 mg
$1099.00

Acetyl coenzyme A trilithium salt, 250 mg

sc-214465D
250 mg
$2599.00

Acetyl coenzyme A trilithium salt, 1 g

sc-214465E
1 g
$6863.00

What is the purity (enzymatic activity)?

Asked by: Lana N
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Tech Service
Date published: 2020-02-28
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Rated 5 out of 5 by from ExcellentWorks great for enzymatic assays, easy to dissolve it water.
Date published: 2021-07-30
Rated 5 out of 5 by from Excellent productThis reagent works nicely for enzymatic activities.
Date published: 2018-04-03
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Acetyl coenzyme A trilithium salt is rated 5.0 out of 5 by 2.
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