Molecular structure of Acetyl chloride, CAS Number: 75-36-5
Acetyl chloride (CAS 75-36-5)
Alternate Names:
Ethanoyl chloride
Application:
Acetyl chloride is an acid chloride reagent used for acetylation
CAS Number:
75-36-5
Purity:
98%
Molecular Weight:
78.50
Molecular Formula:
C2H3ClO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetyl chloride is an acid chloride reagent used for acetylation in organic synthesis reactions such as esterification and the Friedel-Crafts reaction. It has been reported that Acetyl chloride can be used as a fluorescence histochemical in combination with formaldehyde to identify tryptophyl-peptide-containing endocrine cells of the hypophysis. Furthermore, gaseous Acetyl chloride can be used in Fourier-transform infrared emission spectroscopy at 248nm, which can detect fragments of HCl, CO, and CH2 in the presence of Ar or O2. Alternate studies suggest that Acetyl chloride can be used as a derivatizing agent for determining high molecular weight alcohols in fish oil.
Acetyl chloride (CAS 75-36-5) References
- S(N)2 Mechanism for Alcoholysis, Aminolysis, and Hydrolysis of Acetyl Chloride. | Bentley, TW., et al. 1996. J Org Chem. 61: 7927-7932. PMID: 11667754
- Determination of the barrier height for acetyl radical dissociation from acetyl chloride photodissociation at 235 nm using velocity map imaging. | Tang, X., et al. 2008. J Phys Chem B. 112: 16050-8. PMID: 19367922
- Photodissociation of gaseous acetyl chloride at 248 nm by time-resolved Fourier-transform infrared spectroscopy: the HCl, CO, and CH2 product channels. | Liu, YT., et al. 2010. J Phys Chem A. 114: 7275-83. PMID: 20568795
- Assessing an impulsive model for rotational energy partitioning to acetyl radicals from the photodissociation of acetyl chloride at 235 nm. | Womack, CC., et al. 2010. J Phys Chem A. 114: 13005-10. PMID: 21117659
- Acetyl chloride-silver nitrate-acetonitrile: a reagent system for the synthesis of 2-nitroglycals and 2-nitro-1-acetamido sugars from glycals. | Kancharla, PK., et al. 2011. J Org Chem. 76: 5832-7. PMID: 21612270
- [2-Acet-oxy-3-(naphthalen-1-yl-oxy)prop-yl](propan-2-yl)aza-nium chloride monohydrate. | Liu, YY., et al. 2013. Acta Crystallogr Sect E Struct Rep Online. 69: o512. PMID: 23634058
- Synthesis of N-alkoxy-substituted 2H-benzimidazoles. | Ansari, NH. and Söderberg, BCG. 2017. Tetrahedron Lett. 58: 4717-4720. PMID: 29503480
- Physics behind the Barrier to Internal Rotation of an Acetyl Chloride Molecule: A Combined Approach from Density Functional Theory, Car-Parrinello Molecular Dynamics, and Time-Resolved Wavelet Transform Theory. | Dutta, B., et al. 2018. ACS Omega. 3: 6794-6803. PMID: 31458850
- Synthesis of Ethyl Acetohydroximate and Derivatives from Imidate Hydrochloride. | Hyodo, K., et al. 2022. J Org Chem. 87: 2959-2965. PMID: 35077176
- Modification of Pyrrolo[2,1-a]isoquinolines and Polysubstituted Pyrroles via Methylenation with Acetyl Chloride and Dimethylsulfoxide. | Li, WZ., et al. 2022. J Org Chem. 87: 11491-11502. PMID: 35951357
- Detection of the tetrahedral reaction intermediate of the reaction of acetyl chloride with ethanol in microdroplets via laser desorption/ionization tandem mass spectrometry. | Boulos, VM., et al. 2022. Phys Chem Chem Phys. 24: 24690-24694. PMID: 36196956
- Ultrasensitive HPLC-MS Quantification of S-(2-Succino) Cysteine Based on Ethanol/Acetyl Chloride Derivatization in Fumarate Accumulation Cells. | Liu, Y., et al. 2023. Anal Chem.. PMID: 36625376
- Combined formaldehyde and acetyl chloride vapour condensation: a new fluorescence histochemical method for the demonstration of tryptophyl-peptide-containing endocrine cells of the hypophysis. | Partanen, S., et al. 1974. Histochemistry. 41: 119-31. PMID: 4613720
- Use of acetyl chloride/methanol for assumed selective methylation of plasma nonesterified fatty acids results in significant methylation of esterified fatty acids. | Hallaq, Y., et al. 1993. Lipids. 28: 355-60. PMID: 8487628
- A method for preparation of amino acid thiohydantoins from free amino acids activated by acetyl chloride for development of protein C-terminal sequencing. | Mo, B., et al. 1997. Anal Biochem. 249: 207-11. PMID: 9212872
Activator of:
Na+ CP type IIα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl chloride, 25 g | sc-207253 | 25 g | $30.00 | |||
Acetyl chloride, 500 g | sc-207253A | 500 g | $50.00 |