Molecular structure of Acetildenafil, CAS Number: 831217-01-7
Acetildenafil (CAS 831217-01-7)
Alternate Names:
5-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-1,6-dihydro-1-methyl -3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one; Hongdenafil
Application:
Acetildenafil is a structural analog of Sidenafil
CAS Number:
831217-01-7
Purity:
98%
Molecular Weight:
466.58
Molecular Formula:
C25H34N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Acetildenafil, closely related to Sildenafil through its structural analog status, functions primarily as an inhibitor of phosphodiesterase (PDE), specifically targeting the PDE5 enzyme variant. This action facilitates the elevation of cyclic guanosine monophosphate (cGMP) levels within cells, a critical messenger in various biochemical pathways. By inhibiting PDE5, Acetildenafil prevents the breakdown of cGMP, thus potentiating processes that rely on this molecule for signal transduction. In research applications, its utility is derived from its ability to modulate cellular signaling pathways, offering useful for investigating the complex mechanisms underpinning cGMP-related functions.
Acetildenafil (CAS 831217-01-7) References
- Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement. | Reepmeyer, JC. and Woodruff, JT. 2007. J Pharm Biomed Anal. 44: 887-93. PMID: 17532168
- Liquid chromatography ion trap/time-of-flight mass spectrometric study on the fragmentation of an acetildenafil analogue. | Zou, P., et al. 2007. Eur J Mass Spectrom (Chichester). 13: 233-8. PMID: 17881792
- Structural determination of sildenafil and its analogues in dietary supplements by fast-atom bombardment collision-induced dissociation tandem mass spectrometry. | Ahn, S., et al. 2009. Rapid Commun Mass Spectrom. 23: 3158-66. PMID: 19714704
- Sildenafil for pulmonary hypertension complicating idiopathic pulmonary fibrosis: a rationale grounded in basic science. | Hassoun, PM. and Nathan, SD. 2016. Eur Respir J. 47: 1615-7. PMID: 27246075
- Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit. | Russo, FM., et al. 2019. Xenobiotica. 49: 98-105. PMID: 29278046
- An immunochromatographic strip sensor for sildenafil and its analogues. | Wang, Z., et al. 2019. J Mater Chem B. 7: 6383-6389. PMID: 31642841
- Progressive Effects of Sildenafil on Visual Processing in Rats. | Østergaard, FG., et al. 2020. Neuroscience. 441: 131-141. PMID: 32615234
- Effects of sildenafil and tadalafil on skin flap viability. | Souza, RAC., et al. 2022. Arch Dermatol Res. 314: 151-157. PMID: 33715076
- D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction. | de Almeida Rezende, MS., et al. 2021. PLoS One. 16: e0249487. PMID: 33857158
- Effects of sildenafil on right ventricle remodelling in Portopulmonary hypertension. | Rossi, R., et al. 2021. Pulm Pharmacol Ther. 70: 102071. PMID: 34428597
- Protective effects of sildenafil administration on chemotherapeutic-induced ovarian damage in rats. | Ergin, B., et al. 2022. Can J Physiol Pharmacol. 100: 486-491. PMID: 35226516
- Population pharmacokinetic analysis of sildenafil in term and preterm infants with pulmonary arterial hypertension. | Rhee, SJ., et al. 2022. Sci Rep. 12: 7393. PMID: 35513541
- Resurrection of sildenafil: potential for Huntington's Disease, too? | Achenbach, J., et al. 2022. J Neurol. 269: 5144-5150. PMID: 35633374
- Nitric Oxide Signalling in Descending Vasa Recta after Hypoxia/Re-Oxygenation. | Xu, M., et al. 2022. Int J Mol Sci. 23: PMID: 35806018
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetildenafil, 2.5 mg | sc-207250 | 2.5 mg | $388.00 |