Date published: 2025-10-2

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Aceclidine Hydrochloride (CAS 6109-70-2)

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Alternate Names:
3-Acetoxyquinuclidine hydrochloride
Application:
Aceclidine Hydrochloride is a non-selective muscarinic acetylcholine receptor partial agonist
CAS Number:
6109-70-2
Molecular Weight:
205.68
Molecular Formula:
C9H15NO2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Aceclidine hydrochloride is a chemical that functions as a muscarinic receptor agonist, targeting the M1 and M2 subtypes. It acts by binding to these receptors and activating them, leading to the downstream signaling cascade within the cell. This activation results in the modulation of various physiological processes, including smooth muscle contraction, glandular secretion, and heart rate regulation. Aceclidine hydrochloride interacts with the acetylcholine receptors, leading to conformational changes and subsequent intracellular signaling. Aceclidine Hydrochloride′s mechanism of action involves the specific activation of muscarinic receptors, leading to the modulation of cellular responses and physiological functions.


Aceclidine Hydrochloride (CAS 6109-70-2) References

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  2. Mechanism of vascular relaxation by cholinomimetic drugs with special reference to pilocarpine and arecoline.  |  Patil, PN. and Stearns, R. 2002. J Ocul Pharmacol Ther. 18: 25-34. PMID: 11858612
  3. Central muscarinic receptor subtypes and carrageenin-induced paw oedema in rats.  |  Bhattacharya, SK., et al. 1991. Res Exp Med (Berl). 191: 65-76. PMID: 1674619
  4. Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics.  |  Hagan, JJ., et al. 1989. Psychopharmacology (Berl). 98: 347-56. PMID: 2526345
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  6. Chemical Modulators of Fibrinogen Production and Their Impact on Venous Thrombosis.  |  Vilar, R., et al. 2021. Thromb Haemost. 121: 433-448. PMID: 33302304
  7. The effect of perchlorate ion and some pharmacological agents on the sensitivity of the frog (Rana pipiens) rectus abdominis to acetylcholine.  |  Hanin, I. and Jenden, DJ. 1966. Experientia. 22: 537-9. PMID: 4290993
  8. Relationships between the chemical structure and pharmacological activity in a series of synthetic quinuclidine derivatives.  |  Mashkovsky, MD. and Yakhontov, LN. 1969. Prog Drug Res. 13: 293-339. PMID: 4391190
  9. Ophthalmic bioavailability. I. Corneal penetration of aceclidine (3-acetoxyquinuclidine) into the rabbit eye using a perfusion technique.  |  Brian, B., et al. 1974. J Pharm Sci. 63: 633-5. PMID: 4828723
  10. Double-blind cross-over comparison of aceclidine and pilocarpine in open-angle glaucoma.  |  Romano, JH. 1970. Br J Ophthalmol. 54: 510-21. PMID: 4917903
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  12. Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide.  |  Ringdahl, B., et al. 1982. Mol Pharmacol. 21: 594-9. PMID: 6125875
  13. Mediation by the same muscarinic receptor subtype of phasic and tonic contractile activities in the rat isolated portal vein.  |  Pfaffendorf, M. and Van Zwieten, PA. 1993. Br J Pharmacol. 108: 132-8. PMID: 8428203
  14. Aceclidine effects on outflow facility after ciliary muscle disinsertion.  |  Hubbard, WC., et al. 1996. Ophthalmologica. 210: 303-7. PMID: 8878214

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Aceclidine Hydrochloride, 1 g

sc-210735
1 g
$225.00

Aceclidine Hydrochloride, 5 g

sc-210735A
5 g
$750.00