Molecular structure of ACEA, CAS Number: 220556-69-4
ACEA (CAS 220556-69-4)
See product citations (3)
Alternate Names:
arachidonyl-2-chloroethylamide
Application:
ACEA is a potent and selective agonist of the CB1 receptors
CAS Number:
220556-69-4
Purity:
≥95%
Molecular Weight:
365.99
Molecular Formula:
C22H36ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ACEA (Arachidonyl-2-chloroethylamide) can bind to cannabinoid receptors (CB1) with a high affinity of Ki =1.4nM and act as a potent and selective agonist of the CB1 receptors. ACEA does not bind to the CB2 receptor. CB1 receptors are predominantly expressed in the central and peripheral nervous system. Studies show that ACEA displays vasomotor influence by acting through the channel vanilloid receptors 1 (TRPV1) found on capsaicin-sensitive afferent nerves. Research also shows that ACEA can stimulate cAMP accumulation in trigeminal ganglion (TG) neurons in a calcium and TRPV1 dependent manner.
ACEA (CAS 220556-69-4) References
- Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). | Hillard, CJ., et al. 1999. J Pharmacol Exp Ther. 289: 1427-33. PMID: 10336536
- Pharmacology of cannabinoid receptor ligands. | Pertwee, RG. 1999. Curr Med Chem. 6: 635-64. PMID: 10469884
- Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. | Franklin, A. and Stella, N. 2003. Eur J Pharmacol. 474: 195-8. PMID: 12921861
- Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide. | Price, TJ., et al. 2004. Br J Pharmacol. 141: 1118-30. PMID: 15006899
- The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints. | Baker, CL. and McDougall, JJ. 2004. Br J Pharmacol. 142: 1361-7. PMID: 15277316
- Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors. | Rutkowska, M. and Jachimczuk, O. 2004. Acta Pol Pharm. 61: 165-7. PMID: 15493300
- ACEA (arachidonyl-2-chloroethylamide), the selective cannabinoid CB1 receptor agonist, protects against aspirin-induced gastric ulceration. | Rutkowska, M. and Fereniec-Gołtbiewska, L. 2006. Pharmazie. 61: 341-2. PMID: 16649551
- Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. | Luszczki, JJ., et al. 2006. Eur J Pharmacol. 547: 65-74. PMID: 16930590
- Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. | Luszczki, JJ., et al. 2010. Prog Neuropsychopharmacol Biol Psychiatry. 34: 18-25. PMID: 19751793
- Arachidonyl-2-Chloroethylamide Alleviates Cerebral Ischemia Injury Through Glycogen Synthase Kinase-3β-Mediated Mitochondrial Biogenesis and Functional Improvement. | Bai, F., et al. 2017. Mol Neurobiol. 54: 1240-1253. PMID: 26820679
- Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice. | Citraro, R., et al. 2016. Eur J Pharmacol. 791: 523-534. PMID: 27663280
- A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. | Andres-Mach, M., et al. 2017. Int J Mol Sci. 18: PMID: 28441341
- Arachidonyl-2'-chloroethylamide (ACEA), a synthetic agonist of cannabinoid receptor, increases CB1R gene expression and reduces dyskinesias in a rat model of Parkinson's disease. | Leija-Salazar, M., et al. 2020. Pharmacol Biochem Behav. 194: 172950. PMID: 32413434
- Dual action of the cannabinoid receptor 1 ligand arachidonyl-2'-chloroethylamide on calcitonin gene-related peptide release. | Christiansen, IM., et al. 2022. J Headache Pain. 23: 30. PMID: 35189809
- Inhibition of the Human Neuronal Sodium Channel Nav1.9 by Arachidonyl-2-Chloroethylamide, An Analogue of Anandamide in a hNav1.9/rNav1.4 Chimera, An Experimental and in Silico Study. | Marchese-Rojas, M., et al. 2023. Neuroscience. 511: 39-52. PMID: 36156289
Inhibitor of:
JMJD7.Activator of:
CB1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACEA, 5 mg | sc-202902 | 5 mg | $77.00 | |||
ACEA, 25 mg | sc-202902A | 25 mg | $306.00 |