ACE2 Antibody (AC18Z): sc-73668
- ACE2 Antibody (AC18Z) is a mouse monoclonal IgG2a, cited in 18 publications, provided at 100 µg/ml
- raised against amino acids 18-740 of ACE2 of human origin
- recommended for detection of ACE2 of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ACE2 Antibody (AC18Z). This work is in progress.
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ACE2 Antibody (AC18Z) is a mouse monoclonal IgG2a antibody that detects angiotensin-converting enzyme 2 (ACE2) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-ACE2 antibody (AC18Z) plays a crucial role in studying the renin-angiotensin system, primarily functioning as a negative regulator of angiotensin II, which is a potent vasopressor hormone. By converting angiotensin II into angiotensin-(1-7), ACE2 helps to counteract the effects of angiotensin II, thereby promoting vasodilation and reducing blood pressure. This balance is vital for maintaining cardiovascular health and fluid homeostasis, making ACE2 an important target for therapeutic interventions in conditions such as hypertension and heart failure. Additionally, ACE2 is expressed predominantly in cardiac, renal, and testicular tissues, which highlights its significance in organ-specific functions and its potential role in various pathophysiological conditions. ACE2 monoclonal antibody (AC18Z) is an essential tool for researchers investigating the intricate mechanisms of the renin-angiotensin system and its implications in health and disease.
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ACE2 Antibody (AC18Z) References:
- Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator. | Bian, J. and Li, Z. 2021. Acta Pharm Sin B. 11: 1-12. PMID: 33072500
- COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection. | Beyerstedt, S., et al. 2021. Eur J Clin Microbiol Infect Dis. 40: 905-919. PMID: 33389262
- COVID-19-A Theory of Autoimmunity Against ACE-2 Explained. | McMillan, P., et al. 2021. Front Immunol. 12: 582166. PMID: 33833750
- SARS-CoV-2 infection and ACE2 inhibition. | Angeli, F., et al. 2021. J Hypertens. 39: 1555-1558. PMID: 34188002
- Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19. | Shafiee, S., et al. 2021. Cancer Cell Int. 21: 431. PMID: 34399734
- Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. | Kuba, K., et al. 2021. Front Immunol. 12: 732690. PMID: 35003058
- ACE2 pathway regulates thermogenesis and energy metabolism. | Cao, X., et al. 2022. Elife. 11: PMID: 35014608
- ACE2 Shedding and the Role in COVID-19. | Wang, J., et al. 2021. Front Cell Infect Microbiol. 11: 789180. PMID: 35096642
- SARS-CoV-2 down-regulates ACE2 through lysosomal degradation. | Lu, Y., et al. 2022. Mol Biol Cell. 33: ar147. PMID: 36287912
- Autoantibodies against angiotensin-converting enzyme 2 (ACE2) after COVID-19 infection or vaccination. | Tsoi, JYH., et al. 2023. J Med Virol. 95: e29313. PMID: 38100626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ACE2 Antibody (AC18Z) | sc-73668 | 100 µg/ml | $322.00 |