Acatin Antibody (36-X): sc-101305

Acatin Antibody (36-X) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Acatin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Acatin antibody (36-X) is available as the non-conjugated form. Acatin, also known as AT1, AT-1, or SLC33A1 (solute carrier family 33 member 1), is a multi-pass membrane protein that plays a crucial role in transporting acetyl-CoA into the lumen of the Golgi apparatus, a process essential for the O-acetylation of gangliosides. This modification utilizes acetyl-CoA as the acid donor to generate acetylated sialic acid residues on glycoproteins and gangliosides, which are critical for various cellular functions. Acatin is predominantly expressed in the pancreas, heart, brain, lung, liver, placenta, and kidneys, and is located in the membranes of both the Golgi apparatus and the endoplasmic reticulum. The presence of acetylated sialic acid residues on gangliosides enhances the complexity and diversity of sugar chains, which influences pathways such as neural cell differentiation and migration. By facilitating these processes, Acatin plays a significant role in cellular communication and development, making Acatin an important target for research in various biological contexts.

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Acatin Antibody (36-X) References:

1. Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene.  |  Bora, RS., et al. 2000. FEBS Lett. 473: 169-72. PMID: 10812068
2. cDNA cloning of putative rat acetyl-CoA transporter and its expression pattern in brain.  |  Bora, RS., et al. 2000. Cytogenet Cell Genet. 89: 204-8. PMID: 10965123
3. The acetyl-CoA transporter family SLC33.  |  Hirabayashi, Y., et al. 2004. Pflugers Arch. 447: 760-2. PMID: 12739170
4. Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis.  |  Jiang, YM., et al. 2007. J Neuropathol Exp Neurol. 66: 617-27. PMID: 17620987
5. Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated ganglioside: a putative acetyl-CoA transporter.  |  Kanamori, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 2897-902. PMID: 9096318
6. Assignment1 of a putative acetyl-CoA transporter gene (Acatn) to mouse chromosome band 3E1-E3 by in situ hybridization.  |  Bora, RS., et al. 1998. Cytogenet Cell Genet. 83: 78-9. PMID: 9925934