Ac-WVAD-AMC
Alternate Names:
Caspase-1/Caspase-4 Substrate II, Fluorogenic
Application:
Ac-WVAD-AMC is a fluorogenic substrate for caspase-1 and caspase-4
Molecular Weight:
688.7
Molecular Formula:
C35H40N6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A fluorogenic substrate for caspase-1 (kcat/Km = 2.41 x 105 M-1s-1) and caspase-4. Caspase-1/Caspase-4 Substrate II, fluorogenic. Exhibits ~2 fold higher affinity towards caspase-1 than for caspase-4.
Ac-WVAD-AMC References
- A substrate combinatorial array for caspases. | Lee, D., et al. 1999. Bioorg Med Chem Lett. 9: 1667-72. PMID: 10397497
- Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules. | Edelstein, CL., et al. 1999. J Am Soc Nephrol. 10: 1940-9. PMID: 10477146
- Changes of caspase activities involved in apoptosis of a macrophage-like cell line J774.1/JA-4 treated with lipopolysaccharide (LPS) and cycloheximide. | Karahashi, H. and Amano, F. 2000. Biol Pharm Bull. 23: 140-4. PMID: 10706374
- Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. | Zhou, LJ. and Zhu, XZ. 2000. J Pharmacol Exp Ther. 293: 982-8. PMID: 10869401
- Induction of oxidative stress by homocyst(e)ine impairs endothelial function. | Mujumdar, VS., et al. 2001. J Cell Biochem. 82: 491-500. PMID: 11500925
- Caspase-1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products. | Lin, H., et al. 2018. ACS Appl Mater Interfaces. 10: 12173-12180. PMID: 29323474
- Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1β release from human neutrophils than isolates from normal flora. | Månsson, E., et al. 2018. APMIS. 126: 678-684. PMID: 30168623
- Leishmania donovani evades Caspase 1 dependent host defense mechanism during infection. | Saha, G., et al. 2019. Int J Biol Macromol. 126: 392-401. PMID: 30584943
- BLIMP-1 Plays Important Role in the Regulation of Macrophage Pyroptosis for the Growth and Multiplication of Leishmania donovani. | Saha, G., et al. 2019. ACS Infect Dis. 5: 2087-2095. PMID: 31618572
- Preparation of an autolysis-resistant interleukin-1 beta converting enzyme mutant. | Dang, LC., et al. 1996. Biochemistry. 35: 14910-6. PMID: 8942655
- Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes. | Inayat-Hussain, SH., et al. 1997. Hepatology. 25: 1516-26. PMID: 9185777
- A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). | Rano, TA., et al. 1997. Chem Biol. 4: 149-55. PMID: 9190289
- Disulfiram is a potent inhibitor of proteases of the caspase family. | Nobel, CS., et al. 1997. Chem Res Toxicol. 10: 1319-24. PMID: 9437520
Substrate of:
caspase-1, caspase-4, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-WVAD-AMC, 5 mg | sc-300159 | 5 mg | $89.00 | |||
Ac-WVAD-AMC, 50 mg | sc-300159A | 50 mg | $1000.00 |