Molecular structure of Ac-VDVAD-pNA, CAS Number: 189684-53-5
Ac-VDVAD-pNA (CAS 189684-53-5)
Alternate Names:
Caspase-2 substrate
Application:
Ac-VDVAD-pNA is a chromogenic substrate for caspase-2
CAS Number:
189684-53-5
Molecular Weight:
679.7
Molecular Formula:
C29H41N7O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Ac-VDVAD-pNA is a chromogenic substrate for caspase-2. It is the preferred substrate for caspase-2 (Km=53 μM).
Ac-VDVAD-pNA (CAS 189684-53-5) References
- Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells. | Zhuang, S. and Simon, G. 2000. Am J Physiol Cell Physiol. 279: C341-51. PMID: 10913000
- Caspase activation and death induced by yessotoxin in HeLa cells. | Malaguti, C., et al. 2002. Toxicol In Vitro. 16: 357-63. PMID: 12110273
- Bcl-2 blocks apoptosis caused by pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly. | Kanazawa, T., et al. 2002. Biochem Biophys Res Commun. 296: 20-5. PMID: 12147221
- Development of autoimmune exocrinopathy resembling Sjögren's syndrome in estrogen-deficient mice of healthy background. | Ishimaru, N., et al. 2003. Am J Pathol. 163: 1481-90. PMID: 14507655
- Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition. | Fang, B., et al. 2006. J Mol Biol. 360: 654-66. PMID: 16781734
- An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity. | Ferreiro, E., et al. 2006. Neurobiol Dis. 23: 669-78. PMID: 16844381
- Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. | Yu, MS., et al. 2007. Int J Mol Med. 20: 261-8. PMID: 17611646
- Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures. | Yun, CY., et al. 2007. Metab Eng. 9: 406-18. PMID: 17658284
- Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. | Pereira, NA. and Song, Z. 2008. Biochem Biophys Res Commun. 377: 873-7. PMID: 18976637
- Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease. | Arduíno, DM., et al. 2009. Neurochem Int. 55: 341-8. PMID: 19375464
- ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells. | Arduino, DM., et al. 2009. BMB Rep. 42: 719-24. PMID: 19944012
- Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells. | Meshkini, A. and Yazdanparast, R. 2012. Exp Toxicol Pathol. 64: 357-65. PMID: 21074392
- Substrate specificities of caspase family proteases. | Talanian, RV., et al. 1997. J Biol Chem. 272: 9677-82. PMID: 9092497
Substrate of:
caspase-2, and Chromogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-VDVAD-pNA, 1 mg | sc-311279 | 1 mg | $54.00 | |||
Ac-VDVAD-pNA, 5 mg | sc-311279A | 5 mg | $122.00 |