Molecular structure of Ac-VDVAD-AFC, CAS Number: 210344-94-8
Ac-VDVAD-AFC (CAS 210344-94-8)
Alternate Names:
Caspase Substrate (AFC); Ac-Val-Asp-Val-Ala-Asp-AFC
Application:
Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2
CAS Number:
210344-94-8
Molecular Weight:
770.71
Molecular Formula:
C33H41F3N6O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2. It is similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes′ shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage is correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.
Ac-VDVAD-AFC (CAS 210344-94-8) References
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- Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. | Allen, JW., et al. 2001. J Neurosci Res. 65: 45-53. PMID: 11433428
- Specific caspase pathways are activated in the two stages of cerebral infarction. | Benchoua, A., et al. 2001. J Neurosci. 21: 7127-34. PMID: 11549723
- Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis. | He, Q., et al. 2004. Oncogene. 23: 1321-5. PMID: 14647455
- Antiproliferative and apoptotic effects of mycophenolic acid in human B-cell non-Hodgkin lymphomas. | Végso, G., et al. 2007. Leuk Res. 31: 1003-8. PMID: 17320952
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- The execution phase of autophagy associated PCD during insect metamorphosis. | Facey, CO. and Lockshin, RA. 2010. Apoptosis. 15: 639-52. PMID: 20405221
- Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. | Tang, Y., et al. 2011. J Biol Chem. 286: 34147-54. PMID: 21828056
- Identification of AaCASPS7, an effector caspase in Aedes albopictus. | Feng, L., et al. 2016. Gene. 593: 117-125. PMID: 27502418
- Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate. | Kitevska, T., et al. 2014. Biosci Rep. 34: PMID: 27919034
- Substrate specificities of caspase family proteases. | Talanian, RV., et al. 1997. J Biol Chem. 272: 9677-82. PMID: 9092497
Substrate of:
caspase-2, Enzyme, and Fluorogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-VDVAD-AFC, 5 mg | sc-311278 | 5 mg | $317.00 | |||
Ac-VDVAD-AFC, 10 mg | sc-311278A | 10 mg | $525.00 |