Ac-VDVAD-AFC CAS: 210344-94-8
MF: C33H41F3N6O12
MW: 770.71
A fluorogenic substrate for caspase-2.

Ac-VDVAD-AFC (CAS 210344-94-8)

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Alternate Names: Caspase Substrate (AFC); Ac-Val-Asp-Val-Ala-Asp-AFC
Application: Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2
CAS Number: 210344-94-8
Molecular Weight: 770.71
Molecular Formula: C33H41F3N6O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2. It is similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes' shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage is correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.


References

1. Talanian, R.V., et al. 1997. J. Biol. Chem. 272: 9677-9682. PMID: 9092497
2. Ito, A., et al. 1999. Biochim. Biophys. Acta. 1452: 263-274. PMID: 10590315
3. Moriya, R., et al. 2000. FEBS Lett. 484: 253-260. PMID: 11078888

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (20 mM), and DMF (20 mM).
Storage :
Store at -20° C
Boiling Point :
1137.18° C at 760 mmHg (Predicted)
Density :
1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Fluoresence :
λex 400 nm λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44135100
MDL Number :
MFCD04037014
SMILES :
CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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