Ac-VDVAD-AFC is a fluorogenic substrate for caspase-2. It is similar to Ac-VDVAD-AMC but the AFC fluorophore has a greater Stokes' shift upon cleavage. VDVAD has been found to be a preferred cleavage site for caspase-2 (Ich-1L). Increases in Ac-VDVAD-AFC cleavage is correlated with losses in procaspase-2 (conversion to active caspase-2) in human neuroblastoma lines induced to apoptosis with C2-ceramide and NO.
1. Talanian, R.V., et al. 1997. J. Biol. Chem. 272: 9677-9682. PMID: 9092497 2. Ito, A., et al. 1999. Biochim. Biophys. Acta. 1452: 263-274. PMID: 10590315 3. Moriya, R., et al. 2000. FEBS Lett. 484: 253-260. PMID: 11078888
Soluble in DMSO (20 mM), and DMF (20 mM).
Store at -20° C
1137.18° C at 760 mmHg (Predicted)
1.40 g/cm3 (Predicted)
n20D 1.56 (Predicted)
λex 400 nm λem 505 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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