Ac-VAD-pNA
Alternate Names:
Acetyl-Val-Ala-Asp-p-Nitro-Anilide; Ac-Val-Ala-Asp-PNA
Application:
Ac-VAD-pNA is a chromogenic paranitroanilide substrate of caspase-1
Molecular Weight:
465
Molecular Formula:
C20H27N5O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Chromogenic paranitroanilide substrate of caspase-1. Is also cleaved by caspases-3, -4, and -7. Similar to amino acids 114-116 (VHD) of the IL-1B precursor, anendogenous substrate of caspase-1. The release of pNA is monitored at 405 nm (ε=9.160M-1cm-1). A chromogenic caspase-1, 3, 4, 7 substrate.
Ac-VAD-pNA References
- Hypoxia-induced apoptosis of astrocytes is mediated by reduction of Dicer and activation of caspase-1. | Kang, YW., et al. 2020. Cell Biol Int. 44: 1394-1404. PMID: 32129540
Substrate of:
caspase-1, caspase-3, caspase-4, caspase-7, and Chromogenic.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-VAD-pNA, 5 mg | sc-300157 | 5 mg | $105.00 | |||
Ac-VAD-pNA, 50 mg | sc-300157A | 50 mg | $1300.00 |